Human Roundabout Homolog 4 (ROBO4) Protein
1079€ (100 µg)
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935106861
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name
Human Roundabout Homolog 4 (ROBO4) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx692506
tested applications
SDS-PAGE
Description
Human ROBO4 Protein is a recombinant protein from Human produced in HEK293 Cells. A DNA sequence encoding the human ROBO4 (Q8WZ75-1) N-terminal four domains (Met 1-Glu 469) was expressed, with a polyhistidine tag at the C-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Roundabout Homolog 4 (ROBO4) |
| Host | HEK293 cells |
| Origin | Human |
| Observed MW | Molecular Weight: 49 kDa Sequence Fragment: Met1-Glu469 Tag: C-terminal His tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 97% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4, 5% glycerol. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8WZ75-1 |
| Gene ID | 54538 |
| OMIM | 607528 |
| Alias | MRB,AOVD3,ECSM4,Magic roundabout,Roundabout homolog 4 |
| Background | Protein ROBO4 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
ROBO4 (Roundabout Guidance Receptor 4) diverges functionally from other ROBO family members by playing a significant role in vascular biology rather than neural development. It is predominantly expressed in endothelial cells and contributes to maintaining vascular integrity by regulating endothelial cell migration, adhesion, and barrier function. ROBO4 interacts with Slit ligands to inhibit pathological angiogenesis and vascular permeability, which is crucial in conditions like inflammation and cancer. Dysregulation of ROBO4 has been implicated in vascular-related disorders, including tumor angiogenesis and chronic inflammatory diseases, underscoring its potential as a therapeutic target in vascular dysfunction and related pathologies.
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