Human Roundabout Homolog 4 (ROBO4) Protein
247€ (10 µg)
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935106861
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name
Human Roundabout Homolog 4 (ROBO4) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx691265
tested applications
SDS-PAGE
Description
Human Roundabout Homolog 4 Protein is a recombinant protein from Human produced in Human Cells. Recombinant Human Roundabout Homolog 4 is produced by our Mammalian expression system and the target gene encoding Gln28-Arg467 is expressed with a Fc tag at the C-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Roundabout Homolog 4 (ROBO4) |
| Host | Human |
| Origin | Human |
| Observed MW | Molecular Weight: 74.6 kDa Sequence Fragment: Gln28-Arg467 Tag: C-terminal Fc tag |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | PBS, pH7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Store at < -20°C. |
| Dry Ice | No |
| UniProt ID | Q8WZ75-1 |
| Gene ID | 54538 |
| OMIM | 607528 |
| Alias | MRB,AOVD3,ECSM4,Magic roundabout,Roundabout homolog 4 |
| Background | Protein ROBO4 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
ROBO4 (Roundabout Guidance Receptor 4) diverges functionally from other ROBO family members by playing a significant role in vascular biology rather than neural development. It is predominantly expressed in endothelial cells and contributes to maintaining vascular integrity by regulating endothelial cell migration, adhesion, and barrier function. ROBO4 interacts with Slit ligands to inhibit pathological angiogenesis and vascular permeability, which is crucial in conditions like inflammation and cancer. Dysregulation of ROBO4 has been implicated in vascular-related disorders, including tumor angiogenesis and chronic inflammatory diseases, underscoring its potential as a therapeutic target in vascular dysfunction and related pathologies.
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