Human Rh Blood Group, D Antigen (RHD) Protein

Este producto es parte de RHD - Rh blood group D antigen
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494€ (100 µg)

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935106861
info@markelab.com
name
Human Rh Blood Group, D Antigen (RHD) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx651012
tested applications
ELISA, WB, SDS-PAGE

Description

Human RHD Protein is a recombinant Human protein. It isproduced in a Prokaryotic expression system (E. coli).

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Proteins and Peptides
Immunogen Target
Rh Blood Group, D Antigen (RHD)
Host
E. coli
Origin
Human
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 20.12 kDa
Concentration: Prior to lyophilization: 1.06 mg/ml
Sequence Fragment: Asp35-Ser75 + His260-Pro291
Tag: N-terminal His and SUMO tags
Expression
Recombinant
Purity
> 90% (SDS-PAGE)
Size 1
100 µg
Size 2
1 mg
Form
Lyophilized Reconstitute in sterile ddH2O. Do not vortex.
Tested Applications
ELISA, WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Availability
Shipped within 7-15 working days.
Storage
Store at 2-8 °C for up to one week. Store at -20 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q02161
Gene ID
6007
OMIM
111680
Alias
Blood group Rh(D) polypeptide,RH,Rh4,RH30,RhII,RhPI,DIIIc,RHCED,RHDel,RHPII,RhDCw,CD240D,Rh polypeptide 2,Rhesus D antigen
Background
Protein RHD
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

RHD (Rh blood group D antigen), encoded by the RHD gene, is a major component of the Rh blood group system, one of the most clinically significant blood group systems in humans. The Rh system includes a range of antigens, but the D antigen is the most important for its role in blood transfusion compatibility, pregnancy, and disease. The Rh system is widely recognized in transfusion medicine, where the presence or absence of the D antigen determines whether an individual is classified as Rh-positive (Rh+) or Rh-negative (Rh-). The Rh system, particularly the D antigen, plays a crucial role in immune reactions, alloimmunization, and hemolytic disease of the newborn (HDN). The RHD gene is located on chromosome 1 and is closely linked to the RHCE gene, which encodes other Rh antigens, particularly C and E. The Rh proteins, including the D antigen, are integral membrane proteins that span the cell membrane and play an essential role in the transportation of ions and gases across the cell membrane, especially in erythrocytes (red blood cells). The RHD gene codes for the RhD protein, and its expression is key to determining whether an individual expresses the RhD antigen on the surface of their erythrocytes.

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