Human Rh Blood Group, D Antigen (RHD) Protein
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Description
Human RHD Protein is a recombinant Human protein. It isproduced in a Prokaryotic expression system (E. coli).
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Rh Blood Group, D Antigen (RHD) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 20.12 kDa Concentration: Prior to lyophilization: 1.06 mg/ml Sequence Fragment: Asp35-Ser75 + His260-Pro291 Tag: N-terminal His and SUMO tags |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized Reconstitute in sterile ddH2O. Do not vortex. |
| Tested Applications | ELISA, WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at 2-8 °C for up to one week. Store at -20 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q02161 |
| Gene ID | 6007 |
| OMIM | 111680 |
| Alias | Blood group Rh(D) polypeptide,RH,Rh4,RH30,RhII,RhPI,DIIIc,RHCED,RHDel,RHPII,RhDCw,CD240D,Rh polypeptide 2,Rhesus D antigen |
| Background | Protein RHD |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
RHD (Rh blood group D antigen), encoded by the RHD gene, is a major component of the Rh blood group system, one of the most clinically significant blood group systems in humans. The Rh system includes a range of antigens, but the D antigen is the most important for its role in blood transfusion compatibility, pregnancy, and disease. The Rh system is widely recognized in transfusion medicine, where the presence or absence of the D antigen determines whether an individual is classified as Rh-positive (Rh+) or Rh-negative (Rh-). The Rh system, particularly the D antigen, plays a crucial role in immune reactions, alloimmunization, and hemolytic disease of the newborn (HDN). The RHD gene is located on chromosome 1 and is closely linked to the RHCE gene, which encodes other Rh antigens, particularly C and E. The Rh proteins, including the D antigen, are integral membrane proteins that span the cell membrane and play an essential role in the transportation of ions and gases across the cell membrane, especially in erythrocytes (red blood cells). The RHD gene codes for the RhD protein, and its expression is key to determining whether an individual expresses the RhD antigen on the surface of their erythrocytes.
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