Human Retinoic Acid Receptor Alpha (RARa) Protein
208€ (10 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Human Retinoic Acid Receptor Alpha (RARa) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx168676
Tested Applications
WB, SDS-PAGE
Description
Human RARa Protein is a recombinant Human protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Retinoic Acid Receptor Alpha (RARa) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Ser68-Glu173 Tag: N-terminal His tag |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 16.0 kDa |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | P10276 |
| Alias | RAR,NR1B1,RARalpha,Nuclear receptor subfamily 1 group B member 1 |
| Background | Protein RARA |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Background
Retinoic acid receptor alpha (RARA) is a nuclear receptor that mediates the biological effects of retinoic acid, an active metabolite of vitamin A, by regulating gene expression RARA forms a heterodimer with retinoid X receptor (RXR) and binds to retinoic acid response elements (RAREs) in the promoter regions of target genes, controlling processes such as cell growth, differentiation, and apoptosis It plays a pivotal role in embryonic development, immune function, and skin health, and its activity is crucial for maintaining cellular homeostasis During development, RARA influences the differentiation of neural, hematopoietic, and epithelial cells, while in adults, it regulates processes like cell renewal and immune responses Dysregulation of RARA expression or function is linked to several diseases, including cancer, where mutations or overexpression of RARA can lead to the inappropriate activation of genes involved in tumor growth and metastasis It is also implicated in disorders such as acute promyelocytic leukemia (APL), where fusion of RARA with other genes causes abnormal gene expression that promotes leukemia cell proliferation
Productos relacionados
Retinoic Acid Receptor Alpha (RARA) Antibody
RARA Antibody is a Rabbit Polyclonal antibody against RARA. This gene represents a nuclear retinoic acid receptor. The e…
Ver producto
Retinoic Acid Receptor Alpha (RARA) Antibody
RARA Antibody is a Rabbit Polyclonal Antibody against RARA.…
Ver producto
Retinoic Acid Receptor Alpha (RARA) Antibody
Rabbit polyclonal antibody against Retinoic Acid Receptor alpha protein. Immunogen region is Internal.…
Ver producto