Human Receptor Tyrosine-Protein Kinase ErbB-2 (ERBB2) Protein

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935106861
info@markelab.com
Precio
221€ (10 µg)
Protein ERBB2
proveedor
Abbexareference
abx168780Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Human Receptor Tyrosine-Protein Kinase ErbB-2 (ERBB2) Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Background
ERBB2, also known as HER2 (human epidermal growth factor receptor 2), is a receptor tyrosine kinase that is part of the ERBB receptor family. This family consists of four closely related receptors: EGFR (ERBB1), HER2 (ERBB2), HER3 (ERBB3), and HER4 (ERBB4). These receptors play crucial roles in cellular signaling pathways regulating cell growth, differentiation, survival, and apoptosis. ERBB2 is particularly significant due to its role in breast cancer and other cancers, where its overexpression or gene amplification is associated with aggressive tumor behavior and poor prognosis. ERBB2 lacks a direct ligand-binding domain but acts as a co-receptor to enhance signaling when paired with other ERBB family members. Its importance in oncology has led to the development of therapies targeting HER2, such as monoclonal antibodies and tyrosine kinase inhibitors.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Receptor Tyrosine-Protein Kinase ErbB-2 (ERBB2)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 42.2 kDa Observed MW (SDS-PAGE): 42 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Thr23-Gly372 Tag: N-terminal His tag
expression
Recombinant
purity
> 90%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
ERBB2
dry ice
No
availability
Shipped within 5-7 working days.
alias
Receptor tyrosine-protein kinase erbB-2,NEU,NGL,HER2,TKR1,CD340,HER-2,VSCN2,MLN 19,MLN-19,c-ERB2,c-ERB-, HER-2/neu; p185(erbB2),Metastatic lymph node gene 19 protein,Proto-oncogene Neu,Proto-oncogene c-ErbB-2,Tyrosine kinase-type cell surface,p185erbB2 receptor HER2
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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