Human Receptor Tyrosine-Protein Kinase ErbB-2 (ERBB2) Protein

Este producto es parte de ERBB2 - erb-b2 receptor tyrosine kinase 2
Human Receptor Tyrosine-Protein Kinase ErbB-2 (ERBB2) Protein

Pida mas información

935106861

info@markelab.com

Precio

221€ (10 µg)

Protein ERBB2

proveedor

Abbexa

reference

abx168780

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Human Receptor Tyrosine-Protein Kinase ErbB-2 (ERBB2) Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).


Background

ERBB2, also known as HER2 (human epidermal growth factor receptor 2), is a receptor tyrosine kinase that is part of the ERBB receptor family. This family consists of four closely related receptors: EGFR (ERBB1), HER2 (ERBB2), HER3 (ERBB3), and HER4 (ERBB4). These receptors play crucial roles in cellular signaling pathways regulating cell growth, differentiation, survival, and apoptosis. ERBB2 is particularly significant due to its role in breast cancer and other cancers, where its overexpression or gene amplification is associated with aggressive tumor behavior and poor prognosis. ERBB2 lacks a direct ligand-binding domain but acts as a co-receptor to enhance signaling when paired with other ERBB family members. Its importance in oncology has led to the development of therapies targeting HER2, such as monoclonal antibodies and tyrosine kinase inhibitors.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Receptor Tyrosine-Protein Kinase ErbB-2 (ERBB2)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 42.2 kDa Observed MW (SDS-PAGE): 42 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Thr23-Gly372 Tag: N-terminal His tag


expression

Recombinant


purity

> 90%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

ERBB2


dry ice

No


availability

Shipped within 5-7 working days.


alias

Receptor tyrosine-protein kinase erbB-2,NEU,NGL,HER2,TKR1,CD340,HER-2,VSCN2,MLN 19,MLN-19,c-ERB2,c-ERB-, HER-2/neu; p185(erbB2),Metastatic lymph node gene 19 protein,Proto-oncogene Neu,Proto-oncogene c-ErbB-2,Tyrosine kinase-type cell surface,p185erbB2 receptor HER2


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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