Human Receptor Tyrosine Kinase Like Orphan Receptor 2 (ROR2) Protein

Background

ROR2 (Receptor Tyrosine Kinase-Like Orphan Receptor 2) is closely related to ROR1 but has distinct functions, particularly in skeletal and cardiovascular development. ROR2 acts as a coreceptor for Wnt5a in the planar cell polarity pathway, essential for cell movement and polarity during embryogenesis. Mutations in the ROR2 gene have been associated with Robinow syndrome and brachydactyly type B, which are developmental disorders affecting skeletal and facial structures. ROR2 is also implicated in cancer biology, where its expression correlates with aggressive tumor behaviors, including invasion and metastasis. Its dual roles in development and disease make ROR2 a critical player in both developmental biology and oncology research.