Human RAB27B, Member RAS Oncogene Family (RAB27B) Protein
1118€ (100 µg)
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935106861
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name
Human RAB27B, Member RAS Oncogene Family (RAB27B) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx693235
tested applications
SDS-PAGE
Description
Human RAB27B Protein is a recombinant protein from Human produced in HEK293 Cells. A DNA sequence encoding the human RAB27B (NP_004154.2) (Thr2-Lys215) was expressed with an N-terminal polyhistidine tag.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | RAB27B |
| Host | HEK293 cells |
| Assay Type | Activity: Not tested Sequence Fragment: Thr2-Lys215 Tag: N-terminal His tag |
| Origin | Human |
| Observed MW | 26.6 kDa |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Storage: Store lyophilized between -20 °C and -80°C. Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months. Shelf Life: 12 months. |
| Dry Ice | No |
| NCBI Accession | NP_004154.2 |
| Alias | C25KG,Ras-related protein Rab-27B |
| Background | Protein RAB27B |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Endotoxin Level: < 1.0 EU per µg (LAL method). |
Descripción
RAB27B, member RAS oncogene family (RAB27B) is a small GTPase that plays a significant role in intracellular vesicular trafficking, particularly in the movement of secretory vesicles to the plasma membrane It is involved in regulating the exocytosis of lysosome-related organelles, such as melanosomes and secretory granules, which are critical for processes like pigmentation and immune cell function RAB27B regulates the trafficking of proteins and lipids, ensuring proper cellular function and membrane recycling It also plays a role in cell adhesion and migration by controlling the delivery of integrins and other cell surface proteins In immune cells, RAB27B is important for cytotoxic T lymphocyte function, contributing to the release of cytotoxic granules that target and destroy infected or cancerous cells Dysregulation of RAB27B is associated with several diseases, including Griscelli syndrome and autoimmune conditions, where defects in vesicular trafficking impair immune response, pigmentation, and organ function RAB27B also has implications in cancer progression, where altered vesicular trafficking contributes to tumor invasion and metastasis
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