Human RAB11B, Member RAS Oncogene Family (RAB11B) Protein
1157€ (100 µg)
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name
Human RAB11B, Member RAS Oncogene Family (RAB11B) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx693192
tested applications
SDS-PAGE
Description
Human RAB11B Protein is a recombinant protein from Human produced in HEK293 Cells. A DNA sequence encoding the human RAB11B (ABQ59034.1) (Gly2-Cys215) was expressed with a polyhistidine tag at the N-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | RAB11B |
| Host | HEK293 cells |
| Origin | Human |
| Observed MW | Molecular Weight: 26.3 kDa Sequence Fragment: Gly2-Cys215 Tag: N-terminal His tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 100 µg |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | ABQ59034.1 |
| Alias | YPT3,GTP-binding protein YPT3,Ras-related protein Rab-11B |
| Background | Protein RAB11B |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
RAB11B, member RAS oncogene family (RAB11B) is closely related to RAB11A and shares many functions in regulating intracellular vesicular trafficking, particularly in the recycling of endosomal vesicles and the transport of membrane proteins between the late endosomes and the recycling endosomes RAB11B plays a central role in ensuring proper receptor recycling, which is important for maintaining the homeostasis of cell surface protein expression and regulating cell signaling processes, including growth, differentiation, and adhesion It contributes to various cellular functions such as vesicle trafficking, cytokinesis, and microtubule organization, particularly during cell division, ensuring proper vesicle distribution and cytokinesis Furthermore, RAB11B is involved in regulating immune responses, as it affects the trafficking of immune receptors and cytokines, impacting immune cell signaling and function Disruptions in RAB11B’s function are implicated in a wide range of diseases, particularly in cancer, where defective vesicular trafficking leads to altered receptor availability, facilitating uncontrolled cell growth and metastasis Additionally, RAB11B is implicated in neurological diseases, where impairments in vesicular recycling and receptor trafficking contribute to neuronal dysfunction, as well as in metabolic diseases such as obesity and type 2 diabetes, where changes in glucose uptake and insulin sensitivity are associated with altered vesicle trafficking pathways
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