Human Pyruvate Dehydrogenase Complex Component X (PDHX) ELISA Kit

Este producto es parte de PDHX - Pyruvate dehydrogenase protein X
Human Pyruvate Dehydrogenase Complex Component X (PDHX) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

715€ (96 tests)

Elisa kits for PDHX

proveedor

Abbexa

reference

abx382134

Tested Applications

ELISA

reactivity

Human

status

RUO

clonality

Descripción

Human Pyruvate Dehydrogenase Complex Component X (PDHX) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Pyruvate Dehydrogenase Complex Component X (PDHX) concentrations in tissue homogenates, cell lysates and other biological fluids.


Background

PDHX is a component of the pyruvate dehydrogenase complex (PDC) located in the mitochondrial matrix, where it plays a critical role in linking glycolysis to the tricarboxylic acid (TCA) cycle by catalyzing the conversion of pyruvate to acetyl-CoA. PDHX functions as the E3-binding protein, anchoring dihydrolipoamide dehydrogenase (E3) to the PDC core and facilitating the transfer of reducing equivalents between PDC subunits. It is essential for the stability and activity of the PDC, ensuring efficient energy production and metabolic homeostasis. Mutations in PDHX are associated with pyruvate dehydrogenase deficiency, a condition characterized by lactic acidosis, developmental delay, and neurological dysfunction due to impaired mitochondrial energy metabolism. PDHX is expressed ubiquitously in energy-demanding tissues such as the brain, muscle, and liver, where it supports ATP production and metabolic adaptation. Knockout studies demonstrate reduced PDC activity, metabolic imbalances, and severe defects in energy-dependent processes, underscoring its importance in cellular respiration and energy metabolism.

Características del producto

category

ELISA Kits


immunogen target

Pyruvate Dehydrogenase Complex Component X (PDHX)


reactivity

Human


test range

1.56 ng/ml - 100 ng/ml


sensitivity

< 0.54 ng/ml


assay type

Sandwich


assay data

Quantitative


form

Lyophilized


detection method

Colorimetric


sample type

Tissue homogenates, cell lysates and other biological fluids.


size 1

96 tests


size 2

5 × 96 tests


size 3

10 × 96 tests


alias

DLDBP, E3BP, OPDX, PDX1, proX, pyruvate dehydrogenase complex component X, PDHXD


storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.


or code

PDHX


dry ice

No


note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


Quizá le pueda interesar

anti- PDHX antibody

anti- PDHX antibody

proveedor

FineTest

reference

FNab06271

Tested Applications

ELISA, IHC, IP, WB

reactivity

human,mouse,rat

status

RUO

clonality

polyclonal

Required for anchoring dihydrolipoamide dehydrogenase(E3) to the dihydrolipoamide transacetylase(E2) core of the pyruvat...

Precio a consultar

Ver más

Recombinant Human PDHX

Recombinant Human PDHX

proveedor

FineTest

reference

P4048

Tested Applications

Western Blot,ELISA

status

RUO

Precio a consultar

Ver más

Pyruvate Dehydrogenase Complex Component X (PDHX) Antibody

Pyruvate Dehydrogenase Complex Component X (PDHX) Antibody

proveedor

Abbexa

reference

abx004919

Tested Applications

ELISA, WB, IP

reactivity

Human, Mouse, Rat

status

RUO

clonality

Polyclonal

PDHX Antibody is a Rabbit Polyclonal antibody against PDHX. The pyruvate dehydrogenase (PDH) complex is located in the m...

195€ (20 µl)

Ver más