Human PYD And CARD Domain Containing (PYCARD) Protein
403€ (20 µg)
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Name
Human PYD And CARD Domain Containing (PYCARD) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx600046
Tested Applications
SDS-PAGE
Description
Human PYD And CARD Domain Containing (PYCARD) Protein is a recombinant protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | PYD And CARD Domain Containing (PYCARD) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: 1-195 AA. Tag: N-terminal 10x His tag and C-terminal Myc tag |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 29.1 kDa Observed MW: 29 kDa |
| Expression | Recombinant |
| Purity | ≥ 85% (SDS-PAGE) |
| Purification | Affinity purified using IMAC. |
| Size 1 | 20 µg |
| Size 2 | 100 µg |
| Size 3 | 1 mg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Buffer | 10 mM Tris-HCl, pH 8.0, containing 1 mM EDTA, 50% glycerol. |
| Availability | Shipped within 5-15 working days. |
| Storage | Store between 2 to 8°C for up to 1 week. For long-term storage, aliquot and store between -20 to -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9ULZ3 |
| Alias | ASC, CARD5, TMS, TMS-1, TMS1,Apoptosis-associated speck-like protein containing a CARD |
| Background | Protein PYCARD |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Endotoxin Level: Not tested Concentration: 0.5 mg/ml |
Background
PYD and CARD domain containing (PYCARD), also known as ASC (apoptosis-associated speck-like protein containing a CARD), is a bipartite adaptor protein involved in innate immunity and inflammation PYCARD contains both a PYRIN domain (PYD) and a caspase recruitment domain (CARD), which facilitate its interaction with inflammasome components such as NLRP3 and caspase-1 PYCARD is essential for inflammasome assembly, leading to the activation of caspase-1, which processes pro-inflammatory cytokines IL-1β and IL-18 and induces pyroptosis, a form of inflammatory cell death Dysregulation of PYCARD has been implicated in inflammatory diseases such as gout, where it activates inflammasomes in response to uric acid crystals, and in autoimmune disorders including lupus PYCARD is also involved in apoptosis, interacting with pro-apoptotic factors to regulate programmed cell death Its overactivation or suppression has been associated with cancer, neuroinflammation, and metabolic diseases, highlighting its critical role in balancing inflammation and cell survival
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