Human PYD And CARD Domain Containing (PYCARD) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for PYCARD
proveedor
Abbexareference
abx520248Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human PYD And CARD Domain Containing (PYCARD) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human PYD And CARD Domain Containing (PYCARD) concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
PYD and CARD domain containing (PYCARD), also known as ASC (apoptosis-associated speck-like protein containing a CARD), is a bipartite adaptor protein involved in innate immunity and inflammation PYCARD contains both a PYRIN domain (PYD) and a caspase recruitment domain (CARD), which facilitate its interaction with inflammasome components such as NLRP3 and caspase-1 PYCARD is essential for inflammasome assembly, leading to the activation of caspase-1, which processes pro-inflammatory cytokines IL-1β and IL-18 and induces pyroptosis, a form of inflammatory cell death Dysregulation of PYCARD has been implicated in inflammatory diseases such as gout, where it activates inflammasomes in response to uric acid crystals, and in autoimmune disorders including lupus PYCARD is also involved in apoptosis, interacting with pro-apoptotic factors to regulate programmed cell death Its overactivation or suppression has been associated with cancer, neuroinflammation, and metabolic diseases, highlighting its critical role in balancing inflammation and cell survival
Características del producto
category
ELISA Kits
immunogen target
PYD And CARD Domain Containing (PYCARD)
reactivity
Human
test range
0.156 ng/ml - 10 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
ASC, CARD5, TMS, TMS-1, TMS1,Apoptosis-associated speck-like protein containing a CARD
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
PYCARD
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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