Human Protein Z (PROZ) Protein
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Description
Human Protein Z (PROZ) Protein is a Recombinant Human protein expressed in E. coli.
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Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Protein Z (PROZ) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 16.9 kDa Observed MW: 17 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Thr282-Asn400 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Background | Protein PROZ |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
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PROZ protein Z, vitamin K-dependent plasma glycoprotein.It is 62 kDa large and 396 amino acids long.It has four domains: a gla-rich region, two EGF-like domains and a trypsin-like domain.It lacks the serine residue that would make it catalytically active as a serine protease.It is a member of the coagulation cascade, the group of blood proteins that leads to the formation of blood clots.It is vitamin K-dependent, and its functionality is therefore impaired in warfarin therapy.It is a glycoprotein.Although it is not enzymatically active, it is structurally related to several serine proteases of the coagulation cascade: factors VII, IX, X and protein C.The carboxyglutamate residues (which require vitamin K) bind protein Z to phospholipid surfaces.The main role of protein Z appears to be the degradation of factor Xa.This is done by protein Z-related protease inhibitor (ZPI), but the reaction is accelerated 1000-fold by the presence of protein Z.Oddly, ZPI also degrades factor XI, but this reaction does not require the presence of protein Z.In some studies, deficiency states have been associated with a propensity to thrombosis.Others, however, link it to bleeding tendency; there is no clear explanation for this, as it acts physiologically as an inhibitor, and deficiency would logically have led to a predisposition for thrombosis.
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