Human Protein Tyrosine Phosphatase Receptor Type G (PTPRG) Protein

Este producto es parte de PTPR - protein tyrosine phosphatase receptor type
Product Graph
234€ (10 µg)

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935106861
info@markelab.com
name
Human Protein Tyrosine Phosphatase Receptor Type G (PTPRG) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx166249
tested applications
WB, SDS-PAGE

Description

Tyrosine Phosphatase Receptor Type G Protein is a recombinant Human protein expressed in E. coli.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
Protein Tyrosine Phosphatase Receptor Type G (PTPRG)
Host
E. coli
Origin
Human
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 35.2 kDa

Concentration: Prior to lyophilization: 200 µg/ml

Sequence Fragment: Phe848-Ala1119

Tag: N-terminal His tag
Expression
Recombinant
Purity
> 95%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Alias
PTPG,HPTPG,RPTPG,R-PTP-GAMMA,Protein-tyrosine phosphatase gamma,Receptor-type tyrosine-protein phosphatase gamma
Background
Protein PTPRG
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

PTPRG is a receptor-type protein tyrosine phosphatase that plays a key role in tumor suppression, immune regulation, and nervous system development. Structurally, PTPRG contains extracellular carbonic anhydrase-like and fibronectin type III domains, a transmembrane region, and two cytoplasmic phosphatase domains. PTPRG is expressed in various tissues, particularly in the brain and immune system. It regulates cellular signaling by dephosphorylating receptor tyrosine kinases (RTKs), thereby influencing cell proliferation, adhesion, and migration. PTPRG has been identified as a tumor suppressor gene in cancers such as lung, breast, and colorectal cancers. In addition, its involvement in synaptic plasticity and neuronal repair highlights its significance in neurobiology. Loss of PTPRG expression through methylation or mutations contributes to tumorigenesis and neurological disorders.

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