Human Receptor-Type Tyrosine-Protein Phosphatase C / CD45 (PTPRC) Protein
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935106861
info@markelab.com
Precio
225€ (2 µg)
Protein PTPRC
proveedor
Abbexareference
abx073990Tested Applications
SDS-PAGEreactivity
status
RUOclonality
Descripción
Receptor-Type Tyrosine-Protein Phosphatase C is a recombinant enzyme.
Background
PTPRC, also known as CD45, is a receptor-type tyrosine phosphatase primarily expressed in hematopoietic cells. It regulates antigen receptor signaling in lymphocytes by dephosphorylating inhibitory residues on Src family kinases such as Lck and Fyn. Structurally, PTPRC has an extracellular domain, a single transmembrane region, and two cytoplasmic phosphatase domains, with the first being catalytically active. It is critical for T-cell and B-cell activation, development, and immune response regulation. Mutations in PTPRC are linked to severe immunodeficiency disorders, including SCID, and its overexpression is associated with autoimmune diseases and leukemia.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Receptor-Type Tyrosine-Protein Phosphatase C / CD45 (PTPRC)
host
E. coli
form
Liquid
tested applications
SDS-PAGE
size 1
2 µg
size 2
10 µg
size 3
100 µg
expression
Recombinant
purity
> 95% (SDS-PAGE)
storage
Store at 4 °C if the entire vial will be used within 2-4 weeks. Store at -20 °C for long term storage. For long term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze/thaw cycles.
or code
PTPRC
dry ice
No
availability
Shipped within 5-10 working days.
alias
LCA,LY5,B220,CD45,L-CA,T200,CD45R,GP180,IMD105,CD45,Leukocyte common antigen,Receptor-type tyrosine-protein phosphatase C
uniprot id
note
This product is for research use only. <p></p> Not for human consumption, cosmetic, therapeutic or diagnostic use.
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