Human Protein Tyrosine Kinase 6 (PTK6) Protein

Product specifications

Proteins and Peptides

Protein Tyrosine Kinase 6 (PTK6)

E. coli

Human

Unconjugated

Molecular Weight: Calculated MW: 32.9 kDa

Concentration: Prior to lyophilization: 200 µg/ml

Sequence Fragment: Phe191-Thr445

Tag: N-terminal His tag

Recombinant

> 95%

10 µg

50 µg

100 µg

200 µg

500 µg

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.

WB, SDS-PAGE

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.

Shipped within 5-7 working days.

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.

No

BRK,Breast tumor kinase, Tyrosine-protein kinase BRK

Protein PTK6

RUO

This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

Protein Tyrosine Kinase 6 (PTK6), also known as BRK (Breast Tumor Kinase), is a non-receptor tyrosine kinase that is predominantly expressed in epithelial tissues and involved in regulating cell growth, differentiation, and stress responses. PTK6 is structurally similar to Src family kinases but functions independently of membrane localization. It contains an SH3 domain, SH2 domain, and a tyrosine kinase domain. PTK6 is localized in both the nucleus and cytoplasm, where it regulates distinct signaling pathways. In normal epithelial cells, PTK6 regulates differentiation and maintenance of tissue integrity. However, in cancers, particularly breast, colorectal, and prostate cancer, PTK6 is frequently upregulated and promotes cell proliferation, migration, and survival. PTK6 enhances signaling through pathways such as STAT3, AKT, and ERK1/2, contributing to tumor progression. Interestingly, PTK6 can also act as a tumor suppressor under certain conditions by promoting cell differentiation. Beyond cancer, PTK6 is involved in stress responses, including DNA damage repair and oxidative stress resistance. Its dual role in cell survival and differentiation makes PTK6 a potential therapeutic target in oncology.

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The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation.

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