Human Protein argonaute-4 (AGO4) ELISA Kit
715€ (96 tests)
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935106861
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name
Human Protein argonaute-4 (AGO4) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx501297
tested applications
ELISA
Description
Human Protein argonaute-4 (AGO4) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Protein argonaute-4 (AGO4) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Protein argonaute-4 (AGO4) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q9HCK5 |
| Alias | EIF2C4 |
| Background | Elisa kits for AGO4 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
AGO4 is another member of the Argonaute family, sharing structural similarities with AGO1, AGO2, and AGO3, including the PAZ and PIWI domains, but it is also catalytically inactive, lacking slicer activity. AGO4 functions predominantly in miRNA-mediated gene regulation, contributing to translational repression of target mRNAs in the RNA-induced silencing complex (RISC). It is expressed in various tissues but at lower levels compared to AGO2. While AGO4 plays a supportive role in gene silencing, its biological significance is less well understood compared to other Argonaute proteins. Emerging evidence suggests that AGO4 might have specialized roles in stress responses and immune regulation, with its dysregulation potentially linked to aberrant miRNA function in diseases such as cancer and autoimmune disorders, although more research is needed to fully elucidate its functions.
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