Human Protein Arginine Methyltransferase 6 (PRMT6) Protein

Product Graph
1118€ (50 µg)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
Human Protein Arginine Methyltransferase 6 (PRMT6) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx692683
tested applications
SDS-PAGE

Description

Human PRMT6 Protein is a recombinant protein from Human produced in HEK293 Cells. A DNA sequence encoding the human PRMT6 (NP_060607.2) (Met 1-Asp 375) was expressed, fused with a polyhistidine tag at the C-terminus and the flag tag at the N-terminus.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
PRMT6
Host
HEK293 cells
Assay Type
Activity: Not tested
Sequence Fragment: Met1-Asp375
Tag: C-terminal His tag and N-terminal FLAG tag
Origin
Human
Observed MW
44.4 kDa
Expression
Recombinant
Purity
> 95% (SDS-PAGE)
Size 1
50 µg
Form
Lyophilized
Tested Applications
SDS-PAGE
Buffer
Lyophilized from sterile PBS, pH 7.5.
Availability
Shipped within 5-15 working days.
Storage
Storage: Store lyophilized between -20 °C and -80°C.
Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months.
Shelf Life: 12 months.
Dry Ice
No
NCBI Accession
NP_060607.2
Background
Protein PRMT6
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Endotoxin Level: < 1.0 EU per µg (LAL method).

Descripción

Related Products

FNab06792

PRMT6 antibody

Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine(MMA) and asymmetrical dimethylarginine(aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4'(H3K4me2 and H3K4me3). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53. Repression of TP53 blocks cellular senescence(By similarity). Also methylates histone H2A and H4 'Arg-3'(H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta(POLB), leading to the stimulation of its polymerase activity by enhancing DNA binding and processivity. Methylates HMGA1. Regulates alternative splicing events. Acts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1. Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator. May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7(NC).

Ver Producto
P6444

Recombinant Human PRMT6

Ver Producto
abx007070

Protein Arginine Methyltransferase 6 (PRMT6) Antibody

PRMT6 Antibody is a Rabbit Polyclonal Antibody against PRMT6.

Ver Producto