Human Programmed Cell Death Protein 1 (PDCD1) CLIA Kit

Este producto es parte de PDCD1 - programmed cell death 1
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643.5€ (96 tests)

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935106861
info@markelab.com
name
Human Programmed Cell Death Protein 1 (PDCD1) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx195370
tested applications
CLIA

Description

Human Programmed Cell Death Protein 1 (PDCD1) Chemiluminescent Immunoassay (CLIA) Kit is a Chemiluminescent Immunoassay (CLIA) kit against Programmed Cell Death Protein 1 (PDCD1).

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
CLIA Kits
Immunogen Target
Programmed Cell Death Protein 1 (PDCD1)
Reactivity
Human
Detection Method
Chemiluminescent
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
31.2 pg/ml - 2000 pg/ml
Sensitivity
18.8 pg/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Form
Lyophilized
Tested Applications
CLIA
Sample Type
Serum, plasma and other biological fluids.
Availability
Shipped within 5-12 working days.
Storage
 Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
Alias
Protein PD-1,PD1,PD-1,CD279,SLEB2,hPD-1,hPD-l,hSLE1,
Background
CLIA Kits PDCD1
Status
RUO
Note
The validity for this kit is 6 months.   This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

Programmed cell death 1 (PDCD1), commonly referred to as PD-1, is a transmembrane protein and immune checkpoint receptor expressed primarily on the surface of T cells, B cells, and some myeloid cells. PD-1 is encoded by the PDCD1 gene and plays a pivotal role in regulating immune responses by inhibiting T-cell activation, particularly in peripheral tissues during inflammation. It serves as a checkpoint receptor that, when engaged, dampens the immune response, promoting self-tolerance and preventing autoimmune reactions. PD-1 binds to its ligands, PD-L1 (CD274) and PD-L2 (PDCD1LG2), which are expressed on antigen-presenting cells (APCs) and various tissue cells, particularly in inflamed or tumor environments. The PD-1 pathway is critical for maintaining immune homeostasis, particularly in contexts where a controlled immune response is necessary, such as in infection and inflammation, and in preventing autoimmunity. PD-1 is often upregulated in chronic infections and cancer, where it contributes to immune exhaustion by inhibiting the function of T cells that would otherwise target infected or malignant cells. Given its role, PD-1 and its ligands have become significant targets for immunotherapy, especially in oncology, where blocking the PD-1/PD-L1 interaction can reinvigorate anti-tumor immunity.

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