Human Procollagen Type I C-Terminal Propeptide (PICP) ELISA Kit
546€ (96 tests)
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name
Human Procollagen Type I C-Terminal Propeptide (PICP) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx253912
tested applications
ELISA
Description
Human Procollagen I C-Terminal Propeptide (PICP) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human PICP concentrations in Serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Procollagen Type I C-Terminal Propeptide (PICP) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.78 ng/ml - 50 ng/ml |
| Sensitivity | 0.47 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. |
| Availability | Shipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P02452 |
| Alias | C-Propeptide Of Type I Procollagen,Procollagen I Carboxy Terminal Propeptide, P1CP |
| Background | Elisa kits for PICP |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Procollagen Type I C-Terminal Propeptide (PICP) is a cleavage product of type I procollagen, the precursor of type I collagen, which is the most abundant structural protein in the extracellular matrix of connective tissues. PICP is released into the bloodstream during the synthesis of type I collagen, making it a reliable biomarker for collagen synthesis and turnover. It is widely used in clinical and research settings to assess bone formation, as increased levels of PICP correlate with osteoblast activity and are indicative of bone remodeling or conditions such as osteoporosis and metabolic bone diseases. Elevated PICP levels can also occur in fibrotic conditions, including liver fibrosis, cardiac fibrosis, and certain cancers, reflecting excessive collagen deposition in affected tissues. Measurement of PICP is typically performed using immunoassays, and its levels can provide insight into the effectiveness of therapeutic interventions aimed at modulating collagen synthesis or tissue remodeling. Additionally, PICP is a key player in the assembly and stabilization of collagen fibrils, facilitating proper extracellular matrix organization. Dysregulation of PICP processing or collagen deposition can lead to pathological states, highlighting its importance in connective tissue health and disease.
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