Human Pre-B-Lymphocyte Gene 1 (VPREB1) Protein

Product specifications

Proteins and Peptides

Pre-B-Lymphocyte Gene 1 (VPREB1)

E. coli

Human

Unconjugated

Molecular Weight: Calculated MW: 15.8 kDa  Observed MW (SDS-PAGE): 16 kDa
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Leu33-Met135
Tag: N-terminal His tag

Recombinant

> 95%

10 µg

50 µg

100 µg

200 µg

500 µg

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.

WB, SDS-PAGE

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.

Shipped within 5-7 working days.

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.

No

P12018

Immunoglobulin iota chain,IGI,IGVPB,VPREB,CD179a,CD179 antigen-like family member A,Protein VPreB1

Protein VPREB1

RUO

This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

VPREB1 (V-set pre-B cell surrogate light chain 1) is a gene encoding a protein that plays a crucial role in early B-cell development. During the development of B cells in the bone marrow, cells progress through several stages to create a functional B cell receptor (BCR), which is essential for the immune system to identify and respond to foreign antigens. VPREB1 encodes a component of the pre-B cell receptor (pre-BCR), a critical complex that allows for the transition of B cells from the pro-B cell to the pre-B cell stage. The pre-BCR includes the immunoglobulin heavy chain and two surrogate light chain components: the VpreB (encoded by VPREB1) and λ5 proteins. This pre-BCR complex is necessary to ensure only B cells with productive heavy chain gene rearrangements continue to develop, a process known as positive selection. Through interaction with the heavy chain, VPREB1 helps form a structurally similar but transient BCR to stimulate cell proliferation and survival at this early stage. This surrogate light chain helps enforce allelic exclusion, which ensures that each B cell produces a unique antibody specificity by allowing only one immunoglobulin heavy chain allele to be expressed. Thus, VPREB1 is vital for a highly selective B cell repertoire, preventing autoimmunity and contributing to immune diversity.

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