Human Pre-B-Lymphocyte Gene 1 (VPREB1) Protein
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935106861
info@markelab.com
Precio
221€ (10 µg)
Protein VPREB1
proveedor
Abbexareference
abx166562Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Pre-B-Lymphocyte Gene 1 Protein is a recombinant Human protein expressed in E. coli.
Background
VPREB1 (V-set pre-B cell surrogate light chain 1) is a gene encoding a protein that plays a crucial role in early B-cell development. During the development of B cells in the bone marrow, cells progress through several stages to create a functional B cell receptor (BCR), which is essential for the immune system to identify and respond to foreign antigens. VPREB1 encodes a component of the pre-B cell receptor (pre-BCR), a critical complex that allows for the transition of B cells from the pro-B cell to the pre-B cell stage. The pre-BCR includes the immunoglobulin heavy chain and two surrogate light chain components: the VpreB (encoded by VPREB1) and λ5 proteins. This pre-BCR complex is necessary to ensure only B cells with productive heavy chain gene rearrangements continue to develop, a process known as positive selection. Through interaction with the heavy chain, VPREB1 helps form a structurally similar but transient BCR to stimulate cell proliferation and survival at this early stage. This surrogate light chain helps enforce allelic exclusion, which ensures that each B cell produces a unique antibody specificity by allowing only one immunoglobulin heavy chain allele to be expressed. Thus, VPREB1 is vital for a highly selective B cell repertoire, preventing autoimmunity and contributing to immune diversity.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Pre-B-Lymphocyte Gene 1 (VPREB1)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 15.8 kDa Observed MW (SDS-PAGE): 16 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Leu33-Met135 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
VPREB1
dry ice
No
availability
Shipped within 5-7 working days.
alias
Immunoglobulin iota chain,IGI,IGVPB,VPREB,CD179a,CD179 antigen-like family member A,Protein VPreB1
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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