Human Poliovirus Receptor Related Protein 1 / PVRL1 (NECTIN1) Protein

Background

Nectin cell adhesion molecule 1 (NECTIN1) plays a pivotal role in mediating cell-cell adhesion, particularly in synaptic connections and neural tissue organization, where it helps establish stable intercellular junctions. Its function extends to serving as a receptor for herpes simplex virus entry, indicating its dual role in maintaining physiological processes and influencing susceptibility to viral infections. Additionally, NECTIN1 interacts with cadherins and other adhesion molecules to maintain tissue architecture and facilitate neural development.