Human Poliovirus Receptor (PVR) Protein
234€ (10 µg)
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935106861
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name
Human Poliovirus Receptor (PVR) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx068619
tested applications
WB, SDS-PAGE
Description
Recombinant Poliovirus Receptor (PVR) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Poliovirus Receptor (PVR) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 31.4 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met56-Thr309 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P15151 |
| Alias | Poliovirus receptor,PVS,HVED,CD155,NECL5,TAGE4,Necl-5,Nectin-like protein 5 |
| Background | Protein PVR |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
PVR, also known as CD155, is a cell adhesion molecule primarily involved in cell signaling, immune modulation, and viral entry. The gene encoding this protein is found on chromosome 19q13.31, and the protein was initially identified as the receptor for poliovirus, facilitating viral entry into cells. However, PVR is not limited to viral entry functions; it plays a significant role in immune cell interactions, migration, and tissue development. Structurally part of the immunoglobulin superfamily, PVR is widely expressed in various tissues, including epithelial cells, endothelial cells, and immune cells, and is upregulated in certain cancers, suggesting an adaptive role in tumor immune escape mechanisms. This protein is a primary ligand for several immune checkpoints such as DNAM-1 (CD226), TIGIT, and CD96, highlighting its importance in immune system modulation.
