Human Plasminogen Activator Inhibitor 1 (SERPINE1) Protein
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935106861
info@markelab.com
Precio
312€ (20 µg)
Protein SERPINE1
proveedor
Abbexareference
abx694109Tested Applications
SDS-PAGEreactivity
status
RUOclonality
Descripción
Human Plasminogen Activator Inhibitor 1 (SERPINE1) Protein is a recombinant Human protein expressed in HEK293 cells.
Background
SERPINE1, also known as Plasminogen Activator Inhibitor-1 (PAI1), is a serine protease inhibitor that plays a key role in the regulation of fibrinolysis, the process that breaks down blood clots. It belongs to the serpin superfamily, which is a group of proteins involved in the inhibition of proteases. Specifically, SERPINE1 inhibits tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA), both of which are enzymes responsible for converting plasminogen into plasmin, a protease that degrades fibrin, the main component of blood clots. The regulation of PAI-1 levels is crucial for maintaining the balance between clot formation and breakdown in the body. Abnormally high levels of PAI-1 are associated with thrombotic conditions, whereas deficiencies can lead to excessive bleeding.
Características del producto
category
Proteins and Peptides
origin
Human
host
HEK293 cells
host
HEK293 cells
form
Lyophilized Reconstitute in sterile H2O. Do not vortex.
tested applications
SDS-PAGE
size 1
20 µg
size 2
100 µg
observerd MW
Molecular Weight: Calculated MW: 43.8 kDa Observed MW (SDS-PAGE): 48 kDa Sequence Fragment: Val24-Pro402 Tag: C-terminal His tag
expression
Recombinant
purity
>95% (SDS-PAGE)
purification
0.2 μm filtered prior to lyophilization.
buffer
Prior to lyophilization: 20 mM PB, 150 mM NaCl, pH 7.4, containing 5% - 8% Trehalose, Mannitol and 0.01% Tween-80.
storage
Store lyophilized between -20 °C and -80 °C.
or code
SERPINE1
dry ice
No
availability
Shipped within 5-15 working days.
alias
PAI,PAI1,PAI-1,PLANH1,Plasminogen activator inhibitor 1,Endothelial plasminogen activator inhibitor,Serpin E1
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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