Human Plasminogen Activator Inhibitor 1 (SERPINE1) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

493.75€ (96 tests)

proveedor

Abbexa

reference

abx050189

Tested Applications

ELISA

reactivity

Human

status

RUO

clonality

Descripción

Human Plasminogen Activator Inhibitor 1 (SERPINE1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Plasminogen Activator Inhibitor 1 (SERPINE1) concentrations in serum, plasma and other biological fluids.

Background

Inhibitory serpins have been shown to function in processes as diverse as DNA binding, chromatin condensation, immunoregulation ,apoptosis and haemostasis. Serpins are a broadly distributed protease inhibitors that use the conformational change as a mechanism of action. They are central in controlling many important proteolytic cascades. Phylogenetically Serpins superfamily organized in "Clades", named by letters. The following numbers shows the position in the glade. Serpin named as a SERPINXy, (where X is the clade and y is the number within that clade) many serpins also have alternative names from before this classification was proposed. Structuraly Serpinsare three β-sheets (A, B and C), 8-9 α-helices (termed hA-hI) and the reactive center known as reactive center loop (RCL). Plasminogen activator inhibitor-1 (PAI-1) also known as endothelial plasminogen activator inhibitor (SERPINE1) is a protein that in humans is encoded by the SERPINE1 gene. Elevated PAI-1 is a risk factor for thrombosis and atherosclerosis. The PAI-1's function is the inhibition of plasminogen activators (tPA and uPA), an enzyme responsible for the cleavage of plasminogen to the active form plasmin.

Background

Se ha demostrado que las serpinas inhibidoras funcionan en procesos tan diversos como la unión al ADN, la condensación de cromatina, la inmunorregulación, la apoptosis y la hemostasia. Las serpinas son inhibidores de proteasas ampliamente distribuidos que utilizan el cambio conformacional como mecanismo de acción. Son fundamentales para controlar muchas cascadas proteolíticas importantes. Filogenéticamente superfamilia de Serpinas organizada en "Clados", nombradas por letras. Los siguientes números muestran la posición en el claro. Serpin nombrada como SERPINXy (donde X es el clado e y es el número dentro de ese clado). Muchas serpinas también tienen nombres alternativos antes de que se propusiera esta clasificación. Estructuralmente, las Serpins son tres láminas β (A, B y C), 8-9 hélices α (denominadas hA-hI) y el centro reactivo conocido como bucle del centro reactivo (RCL). El inhibidor del activador del plasminógeno-1 (PAI-1), también conocido como inhibidor del activador del plasminógeno endotelial (SERPINE1), es una proteína que en los humanos está codificada por el gen SERPINE1. El PAI-1 elevado es un factor de riesgo de trombosis y aterosclerosis. La función del PAI-1 es la inhibición de los activadores del plasminógeno (tPA y uPA), una enzima responsable de la escisión del plasminógeno en la forma activa plasmina.

Características del producto

immunogen target

Plasminogen Activator Inhibitor 1 (SERPINE1)

reactivity

Human

test range

0.156 ng/ml - 10 ng/ml

sensitivity

0.1 ng/ml

assay type

Sandwich

assay data

Quantitative

detection method

Colorimetric

sample type

Serum,Plasma,Other biological fluids

size 1

96 tests

alias

PAI,PAI1,PAI-1,PLANH1,Plasminogen activator inhibitor 1,Endothelial plasminogen activator inhibitor,Serpin E1

storage

Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit

or code

SERPINE1

dry ice

uniprot id

https://www.uniprot.org/uniprotkb/P05121

note

This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

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