Human Phosphoinositide 3-kinase adapter protein 1 (PIK3AP1) ELISA Kit

Product specifications

ELISA Kits

Phosphoinositide 3-kinase adapter protein 1 (PIK3AP1)

Human

Colorimetric

Quantitative

Sandwich

0.156 ng/ml - 10 ng/ml

< 0.06 ng/ml

Optimal dilutions/concentrations should be determined by the end user.

96 tests

5 × 96 tests

10 × 96 tests

Lyophilized

ELISA

Tissue homogenates, cell lysates and other biological fluids.

Shipped within 5-12 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request.

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

No

Q6ZUJ8

118788

607942

B Cell Adaptor Protein,BCAP

Elisa kits for PIK3AP1

RUO

Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request.
This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

Phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1), also known as BCAP (B-cell adaptor for PI3K), is a key adaptor protein involved in linking receptor-mediated signaling to the activation of phosphoinositide 3-kinase (PI3K) pathways, which are critical for cell survival, proliferation, and immune responses. PIK3AP1 is predominantly expressed in immune cells such as B lymphocytes, where it plays an essential role in B-cell receptor (BCR) signaling, promoting downstream PI3K-mediated activation of Akt and mTOR pathways. This activation facilitates cellular processes like growth, metabolism, and differentiation. PIK3AP1 also functions in Toll-like receptor (TLR) signaling in innate immune cells, such as macrophages, to regulate inflammatory responses and cytokine production. Dysregulation of PIK3AP1 has been implicated in immune disorders, including autoimmunity and immunodeficiency, as well as in cancer, where aberrant PI3K signaling contributes to tumor growth and resistance to apoptosis. Its interactions with signaling molecules, such as SH2 domain-containing proteins, ensure specificity and dynamic regulation of immune and cellular responses. Emerging studies suggest that targeting PIK3AP1 or its associated pathways holds therapeutic potential for modulating immune responses or treating malignancies with hyperactive PI3K signaling.

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