Human PHD finger protein 19 (PHF19) ELISA Kit

Este producto es parte de PHF - PHD finger protein
Human PHD finger protein 19 (PHF19) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

715€ (96 tests)

Elisa kits for PHF19

proveedor

Abbexa

reference

abx538656

Tested Applications

ELISA

reactivity

Human

status

RUO

clonality

Descripción

Human PHD finger protein 19 (PHF19) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human PHD finger protein 19 (PHF19) concentrations in tissue homogenates, cell lysates and other biological fluids.


Background

PHF19 is a chromatin-associated protein that contains a PHD finger domain and functions as a component of the Polycomb repressive complex 2 (PRC2). It regulates gene expression through the methylation of histone H3 on lysine 27 (H3K27me3), contributing to transcriptional repression and chromatin compaction. PHF19 acts as a recruiter of PRC2 to actively transcribed genes, linking gene activation to repression during processes like cellular differentiation, proliferation, and stem cell maintenance. It is highly expressed in embryonic stem cells and proliferative tissues, where it plays roles in developmental programming and epigenetic control. Dysregulation of PHF19 has been linked to cancers, including lymphoma and glioblastoma, where it promotes tumorigenesis through aberrant PRC2 activity and disrupted gene silencing. Knockdown studies reveal impaired PRC2 recruitment, altered histone methylation, and disrupted differentiation, highlighting its role in chromatin regulation, transcriptional repression, and developmental pathways.

Características del producto

category

ELISA Kits


immunogen target

PHD finger protein 19 (PHF19)


reactivity

Human


test range

0.156 ng/ml - 10 ng/ml


assay data

Quantitative


form

Lyophilized


detection method

Colorimetric


sample type

Tissue homogenates, cell lysates and other biological fluids.


size 1

96 tests


alias

MTF2L1, PCL3, TDRD19B,Polycomb-like protein 3,hPCL3


storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.


or code

PHF19


dry ice

No


note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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