Human PHD finger protein 19 (PHF19) ELISA Kit

Pida mas información
935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for PHF19
proveedor
Abbexareference
abx538656Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human PHD finger protein 19 (PHF19) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human PHD finger protein 19 (PHF19) concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
PHF19 is a chromatin-associated protein that contains a PHD finger domain and functions as a component of the Polycomb repressive complex 2 (PRC2). It regulates gene expression through the methylation of histone H3 on lysine 27 (H3K27me3), contributing to transcriptional repression and chromatin compaction. PHF19 acts as a recruiter of PRC2 to actively transcribed genes, linking gene activation to repression during processes like cellular differentiation, proliferation, and stem cell maintenance. It is highly expressed in embryonic stem cells and proliferative tissues, where it plays roles in developmental programming and epigenetic control. Dysregulation of PHF19 has been linked to cancers, including lymphoma and glioblastoma, where it promotes tumorigenesis through aberrant PRC2 activity and disrupted gene silencing. Knockdown studies reveal impaired PRC2 recruitment, altered histone methylation, and disrupted differentiation, highlighting its role in chromatin regulation, transcriptional repression, and developmental pathways.
Características del producto
category
ELISA Kits
immunogen target
PHD finger protein 19 (PHF19)
reactivity
Human
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
MTF2L1, PCL3, TDRD19B,Polycomb-like protein 3,hPCL3
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
PHF19
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
Quizá le pueda interesar
anti- PHF19 antibody

proveedor
FineTestreference
FNab06383Tested Applications
ELISA, WB, IHCreactivity
human,mouse,ratstatus
RUOclonality
polyclonalPrecio a consultar
Ver másPHD Finger Protein 19 (PHF19) Antibody

proveedor
Abbexareference
abx007163Tested Applications
ELISA, WB, IF/ICCreactivity
Human, Mouse, Ratstatus
RUOclonality
PolyclonalPHF19 Antibody is a Rabbit Polyclonal Antibody against PHF19.
195€ (20 µl)
Ver másPHD Finger Protein 19 (PHF19) Antibody

proveedor
Abbexareference
abx029733Tested Applications
ELISA, WBreactivity
Humanstatus
RUOclonality
PolyclonalPHF19 acts as a transcritpional repressor. Isoform 1 and isoform 2 inhibit transcription from an HSV-tk promoter.
292.5€ (80 µl)
Ver más