Human Paxillin (Pax) CLIA Kit
845€ (96 tests)
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name
Human Paxillin (Pax) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx493154
tested applications
CLIA
Description
Human Paxillin (Pax) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Tissue homogenates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | CLIA Kits |
| Immunogen Target | Paxillin (Pax) |
| Reactivity | Human |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.055 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Tissue homogenates and other biological fluids. |
| Availability | Shipped within 5-20 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P49023, F5GZ78, F5H836, F8W0K8, F8W0G0, F8W1E0, F8VZ41 |
| Alias | PAX,testicular Tissue Protein Li 134 |
| Background | CLIA Kits PXN |
| Status | RUO |
| Note | The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Paxillin (PXN) is a focal adhesion-associated adaptor protein that regulates cell adhesion, migration, and cytoskeletal organization by interacting with integrins, growth factor receptors, and signaling proteins at focal adhesions. It contains LIM domains and LD motifs, enabling it to recruit structural and signaling molecules such as focal adhesion kinase (FAK), vinculin, and Src kinases, coordinating actin cytoskeletal dynamics and mechanotransduction. Paxillin is critical for integrin-mediated signaling pathways, linking extracellular matrix (ECM) cues to intracellular processes like cell movement, proliferation, and survival. It plays a key role in embryonic development, tissue remodeling, and wound healing by modulating focal adhesion turnover and actomyosin contractility. Dysregulation of paxillin promotes cancer progression, metastasis, and drug resistance by enhancing cell migration, invasion, and survival signaling. Knockout studies reveal defects in focal adhesion formation, impaired cell motility, and developmental abnormalities, highlighting its essential role in cell adhesion, cytoskeletal regulation, and mechanotransduction.
