Human Paired Box Protein Pax-7 (PAX7) ELISA Kit
715€ (96 tests)
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935106861
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name
Human Paired Box Protein Pax-7 (PAX7) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx382073
tested applications
ELISA
Description
Human Paired Box Protein Pax-7 (PAX7) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human PAX7 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Paired Box Protein Pax-7 (PAX7) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.312 ng/ml - 20 ng/ml |
| Sensitivity | < 0.15 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P23759 |
| Gene ID | 5081 |
| OMIM | 167410 |
| Alias | CMYP19,HUP1,MYOSCO,PAX7B,RMS2 |
| Background | Elisa kits for PAX7 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
PAX7 is a transcription factor essential for the specification and maintenance of skeletal muscle satellite cells, which are responsible for muscle growth, repair, and regeneration. It is expressed during embryonic development and in adult muscle progenitor cells, where it regulates myogenesis by activating target genes involved in muscle lineage commitment. PAX7 cooperates with MyoD to ensure muscle cell proliferation while inhibiting premature differentiation. In cancer, PAX7 is implicated in alveolar rhabdomyosarcoma through chromosomal translocations that generate oncogenic fusion proteins, such as PAX7-FOXO1, promoting tumorigenesis and cell survival. Knockout models of PAX7 exhibit impaired satellite cell maintenance, muscle regeneration failure, and reduced muscle mass. Its essential role in skeletal muscle homeostasis and regenerative biology positions PAX7 as a key player in muscle-related disorders, stem cell biology, and tumorigenesis.
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This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box 7 gene is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Three transcript variants encoding different isoforms have been found for this gene.
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