Human Paired Box Protein Pax-1 (PAX1) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for PAX1
proveedor
Abbexareference
abx382068Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Paired Box Protein Pax-1 (PAX1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human PAX1 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
PAX1 is a transcription factor that belongs to the paired box (PAX) family, which regulates embryonic development and tissue differentiation. PAX1 is essential for skeletal development, particularly in vertebral column formation, where it controls the proliferation and differentiation of mesodermal cells into sclerotome-derived structures. It binds DNA through its paired domain and activates the transcription of genes involved in chondrogenesis and axial skeletal patterning. Mutations or deletions in PAX1 are associated with congenital vertebral anomalies and conditions such as oto-spondylo-megaepiphyseal dysplasia (OSMED), characterized by skeletal abnormalities and hearing loss. PAX1 is also expressed in thymic epithelial cells, where it may contribute to thymus development and T cell maturation. Loss-of-function studies in mice reveal vertebral malformations, impaired cartilage differentiation, and developmental defects, underscoring PAX1's role in skeletal morphogenesis, chondrogenesis, and embryonic tissue development.
Características del producto
category
ELISA Kits
immunogen target
Paired Box Protein Pax-1 (PAX1)
reactivity
Human
test range
0.156 ng/ml - 10 ng/ml
sensitivity
< 0.07 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
OFC2,HUP48,OTFCS2
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
PAX1
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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