Human Paired Box Gene 8 (PAX8) ELISA Kit

Este producto es parte de PAX - Paired box protein Pax
Human Paired Box Gene 8 (PAX8) ELISA Kit
715€ (96 tests)

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Name
Human Paired Box Gene 8 (PAX8) ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx257298

Description

Human Paired Box Gene 8 (PAX8) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human PAX-8 concentrations in tissue homogenates, cell lysates and other biological fluids.

Documentos del producto

Instrucciones
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Data sheet
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Especificaciones del producto

Category
ELISA Kits
Immunogen Target
Paired Box Gene 8 (PAX8)
Reactivity
Human
Detection Method
Colorimetric
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
0.156 ng/ml - 10 ng/ml
Sensitivity
< 0.06 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Size 2
5 × 96 tests
Size 3
10 × 96 tests
Form
Standard Form: Lyophilized
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-12 working days.
Storage
Shipped at 4°C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
Q06710
Gene ID
7849
Alias
PAX-8
Background
Elisa Kits for: PAX8
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.

Background

PAX8 is a transcription factor required for the development of the thyroid gland, kidneys, and parts of the reproductive system. During embryogenesis, PAX8 regulates genes necessary for thyroid follicular cell differentiation and hormone synthesis, making it essential for thyroid gland formation and function. Mutations in PAX8 are associated with congenital hypothyroidism, thyroid dysgenesis, and impaired thyroglobulin production. PAX8 also plays a role in nephrogenesis, contributing to kidney development and epithelial cell differentiation. In cancers, PAX8 is frequently overexpressed in thyroid, ovarian, and renal cell carcinomas, where it serves as a diagnostic marker and regulator of oncogenic pathways. Knockout models show thyroid gland agenesis, defective renal development, and reproductive abnormalities, highlighting PAX8's role in tissue-specific gene regulation, organogenesis, and endocrine function.

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