Human Alpha-1-Acid Glycoprotein 2 (ORM2) Protein

Product specifications

Proteins and Peptides

Alpha-1-Acid Glycoprotein 2 (ORM2)

HEK293 cells

Human

Unconjugated

Molecular Weight: Calculated MW: 22 kDa  Observed MW: 30-50 kDa
Sequence Fragment: Met1-Ser201
Tag: C-terminal His tag

Recombinant

> 95% (SDS-PAGE)

20 µg

100 µg

Lyophilized Reconstitute in sterile H2O to prepare a stock solution of concentration 0.5 mg/ml.

SDS-PAGE

Prior to lyophilization: PBS pH 7.4.

Shipped within 5-15 working days.

Store lyophilized below -20°C. After reconstitution, store at 4 °C for up to 1 week, or below -20°C for 3 months. Avoid repeated freeze/thaw cycles.

No

P19652

AGP2,AGP-B,AGP-B,Orosomucoid 2,OMD 2,Orosomucoid-2

Protein ORM2

RUO

This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

Alpha-1-acid glycoprotein 2 (ORM2), also known as orosomucoid 2, is a major acute-phase protein predominantly produced in the liver and secreted into the bloodstream. ORM2 belongs to the lipocalin family, a group of small proteins characterized by their ability to bind and transport small hydrophobic molecules, including drugs, steroids, and lipids. As an acute-phase reactant, ORM2 levels increase significantly in response to inflammation, infection, trauma, or other physiological stresses, playing a critical role in the systemic inflammatory response.ORM2 is closely related to ORM1 (Alpha-1-acid glycoprotein 1), with both proteins sharing high sequence and structural homology. Together, they constitute the majority of the alpha-1-globulin fraction in human plasma. ORM2 has immunomodulatory functions, influencing immune cell activity, vascular permeability, and interactions between cytokines. Additionally, ORM2 is significant in pharmacology because it binds to various drugs, impacting their bioavailability and pharmacokinetics.

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ORM2 antibody

ORM2, also named as AGP2 and OMD 2, belongs to the calycin superfamily and Lipocalin family. It functions as transport protein in the blood stream. ORM2 binds various hydrophobic ligands in the interior of its beta-barrel domain. It also binds synthetic drugs and influences their distribution and availability. ORM2 appears to function in modulating the activity of the immune system during the acute-phase reaction. ORM2 is one of the conserved endoplasmic reticulum membrane proteins which regulating lipid homeostasis and protein quality control. This antibody can recognize both ORM1 and ORM2.

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