Human Nucleoporin 85 kDa (NUP85) Protein

Documentos del producto

Especificaciones del producto

Proteins and Peptides

Nucleoporin 85kDa (NUP85)

E. coli

Activity: Not tested
Sequence Fragment: Arg130-Leu368
Tag: N-terminal His tag

Human

Unconjugated

Calculated MW: 30.9 kDa

Recombinant

> 95%

10 µg

50 µg

100 µg

200 µg

500 µg

Lyophilized

WB, SDS-PAGE

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.

Shipped within 5-7 working days.

Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles.

No

Q9BW27

Nup75,FROUNT,NPHS17,nucleoporin 85kDa,Nuclear pore complex protein Nup85,Nucleoporin Nup75,Nucleoporin Nup85,Pericentrin-1

Protein NUP85

RUO

THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Concentration: Prior to lyophilization: 200 µg/ml

Background

Nucleoporin 85 (NUP85) is a key structural component of the nuclear pore complex, critical for regulating the transport of large macromolecules, such as RNA and proteins, between the nucleus and cytoplasm NUP85 is involved in maintaining the architecture of the nuclear pore, ensuring that molecular trafficking is highly selective and efficient It participates in both nuclear import and export processes by forming part of the pore's central channel and interacting with various transport factors that help shuttle molecules across the nuclear envelope NUP85 plays an important role in gene expression regulation, RNA processing, and protein synthesis by facilitating the movement of factors that control these cellular processes Dysregulation of NUP85 expression or function can lead to a variety of diseases, including cancer, where defects in nucleocytoplasmic transport contribute to altered gene expression and defective cellular processes NUP85 also has a role in cellular responses to environmental stress, helping to maintain the stability of the nucleus and ensuring proper cellular functioning during stress and repair processes By supporting key signaling pathways and the maintenance of cellular integrity, NUP85 plays a critical role in both normal cellular activities and in the prevention of diseases like cancer, making it an important regulator of cellular homeostasis