Human Nucleoporin 50 kDa (NUP50) Protein
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Description
Nucleoporin 50 kDa Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Nucleoporin 50kDa (NUP50) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 27.8 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Asn37-Ala269 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UKX7 |
| Alias | NPAP60,NPAP60L,nucleoporin 50kDa,Nuclear pore-associated protein 60 kDa-like |
| Background | Protein NUP50 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Nucleoporin 50 (NUP50) is another key nucleoporin involved in the transport of proteins and RNA across the nuclear envelope NUP50 functions as a shuttle protein in the process of nuclear import, facilitating the recycling of importin proteins, which are required for the delivery of cargo molecules into the nucleus It is involved in the release of cargo from importins at the nuclear pore and aids in the efficient transport of proteins involved in various cellular processes such as signal transduction, gene regulation, and DNA repair NUP50’s role in nuclear import is crucial for maintaining cellular function, as defects in this process can lead to impaired gene expression, cell cycle progression, and protein localization Dysregulation of NUP50 has been implicated in diseases such as cancer, where alterations in nuclear import and protein trafficking contribute to tumor progression and metastasis
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The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins that functions as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import. Pseudogenes of this gene are found on chromosomes 5, 6, and 14. Two transcript variants encoding different isoforms have been found for this gene. This antibody is supplied as crude ascites.
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