Human Nucleolar Protein 3 (NOL3) Protein
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Human Nucleolar Protein is a recombinant protein from Human produced in E. coli. Recombinant Human Nucleolar Protein 3 is produced by our E.coli expression system and the target gene encoding Met1-Ser208 is expressed.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Nucleolar Protein 3 (NOL3) |
| Host | E. coli |
| Origin | Human |
| Observed MW | Molecular Weight: 22.6 kDa Sequence Fragment: Met1-Ser208 Tag: His tag Validity: The validity for this protein is 6 months. |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Tested Applications | SDS-PAGE |
| Buffer | 25mM TrisHCl, 1mM DTT, 1mM EDTA, 2mM β-ME, 20% Glycerol, pH 7.5. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at < -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O60936 |
| Gene ID | 8996 |
| OMIM | 605235 |
| Background | Protein NOL3 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Related Products
NOL3 antibody
Isoform 1: May be involved in RNA splicing. Isoform 2: Functions as an apoptosis repressor that blocks multiple modes of cell death. Inhibits extrinsic apoptotic pathways through two different ways. Firstly by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex(DISC) assembly(By similarity). Secondly by interacting with CASP8 in a mitochondria localization-and phosphorylation-dependent manner, limiting the amount of soluble CASP8 available for DISC-mediated activation(By similarity). Inhibits intrinsic apoptotic pathway in response to a wide range of stresses, through its interaction with BAX resulting in BAX inactivation, preventing mitochondrial dysfunction and release of pro-apoptotic factors(PubMed:15004034). Inhibits calcium-mediated cell death by functionning as a cytosolic calcium buffer, dissociating its interaction with CASP8 and maintaining calcium homeostasis(PubMed:15509781). Negatively regulates oxidative stress-induced apoptosis by phosphorylation-dependent suppression of the mitochondria-mediated intrinsic pathway, by blocking CASP2 activation and BAX translocation(By similarity). Negatively regulates hypoxia-induced apoptosis in part by inhibiting the release of cytochrome c from mitochondria in a caspase-independent manner(By similarity). Also inhibits TNF-induced necrosis by preventing TNF-signaling pathway through TNFRSF1A interaction abrogating the recruitment of RIPK1 to complex I(By similarity). Finally through its role as apoptosis repressor, promotes vascular remodeling through inhibition of apoptosis and stimulation of proliferation, in response to hypoxia(By similarity). Inhibits too myoblast differentiation through caspase inhibition(By similarity).
Ver Producto
Recombinant Human NOL3
Ver Producto