Human Nuclear Receptor Subfamily 1, Group D, Member 1 (NR1D1) Protein
208€ (10 µg)
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935106861
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name
Human Nuclear Receptor Subfamily 1, Group D, Member 1 (NR1D1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx650547
tested applications
WB, SDS-PAGE
Description
Human NR1D1 Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Nuclear Receptor Subfamily 1, Group D, Member 1 (NR1D1) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 38.3 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met1-Ala325 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P20393 |
| Alias | EAR1,hRev,THRA1,THRAL,ear-1,REVERBA,REVERBalpha,V-erbA-related protein 1 |
| Background | Protein NR1D1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Nuclear receptor subfamily 1 group D member 1 (NR1D1), also known as Rev-Erbα, is a nuclear receptor that plays a key role in regulating the circadian rhythm, metabolism, and inflammation NR1D1 functions by binding to DNA and regulating the expression of genes involved in lipid metabolism, glucose homeostasis, and inflammatory responses It works in opposition to other nuclear receptors, such as RORs (retinoic acid receptor-related orphan receptors), to control circadian clock genes and maintain the balance between the sleep-wake cycle and metabolic processes NR1D1 also has a role in regulating the immune system, where it modulates the expression of genes involved in immune responses and inflammatory pathways Dysregulation of NR1D1 expression or activity has been linked to metabolic disorders, such as obesity, diabetes, and cardiovascular diseases, as well as immune-related conditions like atherosclerosis and rheumatoid arthritis Its involvement in the regulation of daily metabolic rhythms also makes NR1D1 a potential target for therapies aimed at treating sleep disorders, metabolic diseases, and chronic inflammatory conditions
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