Human Notch Homolog 3 (NOTCH3) Protein

Este producto es parte de NOTCH - Neurogenic locus notch homolog protein
Human Notch Homolog 3 (NOTCH3) Protein

Pida mas información

935106861

info@markelab.com

Precio

221€ (10 µg)

Protein NOTCH3

proveedor

Abbexa

reference

abx168112

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Notch Homolog 3 Protein is a recombinant Human protein expressed in E. coli.


Background

NOTCH3 is a receptor in the Notch signaling pathway that primarily regulates vascular smooth muscle cell differentiation, stability, and proliferation. Ligand binding triggers cleavage and release of the NOTCH3 intracellular domain (NICD), which activates gene transcription to maintain vascular integrity. NOTCH3 is highly expressed in arterial smooth muscle cells, where it supports vessel structure and function. Mutations in NOTCH3 cause CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy), a genetic disorder characterized by recurrent strokes, dementia, and vascular dysfunction due to smooth muscle cell degeneration. NOTCH3 is also implicated in tumor biology, where its dysregulation contributes to cancer cell survival, metastasis, and angiogenesis. Knockout studies show defects in vascular development and smooth muscle cell maintenance, emphasizing its role in vascular homeostasis, cell differentiation, and disease pathology.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Notch Homolog 3 (NOTCH3)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 59.2 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Leu2053-Gln2318 Tag: N-terminal His tag and GST tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

NOTCH3


dry ice

No


availability

Shipped within 5-7 working days.


alias

CADASIL,CADASIL1,CASIL,IMF2,LMNS,notch receptor 3


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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clonality

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