Human Notch Homolog 3 (NOTCH3) Protein
221€ (10 µg)
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935106861
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name
Human Notch Homolog 3 (NOTCH3) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx168112
tested applications
WB, SDS-PAGE
Description
Notch Homolog 3 Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Notch Homolog 3 (NOTCH3) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 59.2 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Leu2053-Gln2318 Tag: N-terminal His tag and GST tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UM47 |
| Alias | CADASIL,CADASIL1,CASIL,IMF2,LMNS,notch receptor 3 |
| Background | Protein NOTCH3 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
NOTCH3 is a receptor in the Notch signaling pathway that primarily regulates vascular smooth muscle cell differentiation, stability, and proliferation. Ligand binding triggers cleavage and release of the NOTCH3 intracellular domain (NICD), which activates gene transcription to maintain vascular integrity. NOTCH3 is highly expressed in arterial smooth muscle cells, where it supports vessel structure and function. Mutations in NOTCH3 cause CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy), a genetic disorder characterized by recurrent strokes, dementia, and vascular dysfunction due to smooth muscle cell degeneration. NOTCH3 is also implicated in tumor biology, where its dysregulation contributes to cancer cell survival, metastasis, and angiogenesis. Knockout studies show defects in vascular development and smooth muscle cell maintenance, emphasizing its role in vascular homeostasis, cell differentiation, and disease pathology.
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