Human Neurogenic Locus Notch Homolog Protein 2 (NOTCH2) CLIA Kit
845€ (96 tests)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Human Neurogenic Locus Notch Homolog Protein 2 (NOTCH2) CLIA Kit
Category
CLIA Kits
Provider
Abbexa
Reference
abx495888
Tested Applications
CLIA
Description
Human Neurogenic Locus Notch Homolog Protein 2 (NOTCH2) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Tissue homogenates, cell lysates and other biological fluids.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | CLIA Kits |
| Immunogen Target | Neurogenic Locus Notch Homolog Protein 2 (NOTCH2) |
| Reactivity | Human |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.781 ng/ml - 50 ng/ml |
| Sensitivity | < 0.31 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Standard: Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-20 working days. |
| Storage | Shipped at 4°C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q04721 |
| Gene ID | 4853 |
| OMIM | 102500 |
| Alias | AGS2,HJCYS,hN2,notch receptor 2 |
| Background | CLIA Kits NOTCH2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout. |
Background
NOTCH2 is a key receptor in the Notch signaling pathway that regulates cell proliferation, differentiation, and tissue patterning during development. Ligand binding induces proteolytic cleavage, releasing the NOTCH2 intracellular domain (NICD), which activates transcription of target genes to control cell fate decisions. NOTCH2 is particularly critical for organogenesis, including kidney development, where it regulates nephron formation and podocyte differentiation. Dysregulation of NOTCH2 is linked to various pathologies, including Alagille syndrome, where mutations impair liver, heart, and kidney development. NOTCH2 also plays a role in cancer, where aberrant signaling promotes tumorigenesis, particularly in breast, pancreatic, and biliary tract cancers. Knockout models demonstrate defects in kidney morphogenesis, osteoclast development, and hematopoiesis, highlighting NOTCH2’s essential role in organ development, cellular differentiation, and disease progression.
Productos relacionados
Neurogenic Locus Notch Homolog Protein 2 (NOTCH2) Antibody
NOTCH2 Antibody is a Rabbit Polyclonal Antibody against NOTCH2.…
Ver producto
Neurogenic Locus Notch Homolog Protein 2 Cleaved-Asp1733 (NOTCH2 Cleaved-D1733) Antibody
Rabbit polyclonal antibody against Notch 2 protein. Immunogen region is Internal. Specificity is as follows for the reac…
Ver producto
Neurogenic Locus Notch Homolog Protein 2 Cleaved-Ala1734 (NOTCH2 Cleaved-A1734) Antibody
Rabbit polyclonal antibody against NOTCH2 protein. Immunogen region is Internal. Specificity is as follows for the react…
Ver producto