Human Nicotinamide Nucleotide Adenylyltransferase 1 (NMNAT1) Protein
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Description
Human NMNAT1 Protein is a recombinant protein from Human produced in Baculovirus-Insect Cells. A DNA sequence encoding the human NMNAT1 (Q9HAN9)( Met 1-Thr279) was expressed with a C-terminal polyhistidine tag.
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Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | NMNAT1 |
| Host | Insect |
| Origin | Human |
| Observed MW | Molecular Weight: 33.3 kDa Sequence Fragment: Met1-Thr279 Tag: C-terminal His tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 85% (SDS-PAGE) |
| Size 1 | 50 µg |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile 20mM Tris, 500mM NaCl, 3mM DTT, 10% glycerol, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9HAN9 |
| Background | Protein NMNAT1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
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NMNAT1 antibody
Catalyzes the formation of NAD(+) from nicotinamide mononucleotide(NMN) and ATP(PubMed:17402747). Can also use the deamidated form; nicotinic acid mononucleotide(NaMN) as substrate with the same efficiency(PubMed:17402747). Can use triazofurin monophosphate(TrMP) as substrate(PubMed:17402747). Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+)(PubMed:17402747). For the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate(NHD) and nicotinamide guanine dinucleotide(NGD) less effectively(PubMed:17402747). Involved in the synthesis of ATP in the nucleus, together with PARP1, PARG and NUDT5(PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming(PubMed:27257257). Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+)(PubMed:17402747). Protects against axonal degeneration following mechanical or toxic insults(By similarity).
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