Human Nicotinamide Nucleotide Adenylyltransferase 1 (NMNAT1) Protein
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Description
Nicotinamide Nucleotide Adenylyltransferase 1 is a recombinant enzyme.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Nicotinamide Nucleotide Adenylyltransferase 1 (NMNAT1) |
| Host | E. coli |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Origin | Human |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 5 µg |
| Size 2 | 20 µg |
| Size 3 | 1 mg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Availability | Shipped within 5-10 working days. |
| Storage | Store at 4 °C if the entire vial will be used within 2-4 weeks. Store at -20 °C for long term storage. For long term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9HAN9 |
| Background | Protein NMNAT1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
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NMNAT1 antibody
Catalyzes the formation of NAD(+) from nicotinamide mononucleotide(NMN) and ATP(PubMed:17402747). Can also use the deamidated form; nicotinic acid mononucleotide(NaMN) as substrate with the same efficiency(PubMed:17402747). Can use triazofurin monophosphate(TrMP) as substrate(PubMed:17402747). Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+)(PubMed:17402747). For the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate(NHD) and nicotinamide guanine dinucleotide(NGD) less effectively(PubMed:17402747). Involved in the synthesis of ATP in the nucleus, together with PARP1, PARG and NUDT5(PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming(PubMed:27257257). Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+)(PubMed:17402747). Protects against axonal degeneration following mechanical or toxic insults(By similarity).
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