Human Neuronal Apoptosis Inhibitory Protein (NAIP) CLIA Kit
643.5€ (96 tests)
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935106861
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name
Human Neuronal Apoptosis Inhibitory Protein (NAIP) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx197338
tested applications
CLIA
Description
Human Neuronal Apoptosis Inhibitory Protein (NAIP) Chemiluminescent Immunoassay (CLIA) Kit is a Chemiluminescent Immunoassay (CLIA) kit against Neuronal Apoptosis Inhibitory Protein (NAIP).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | CLIA Kits |
| Immunogen Target | Neuronal Apoptosis Inhibitory Protein (NAIP) |
| Reactivity | Human |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 31.2 pg/ml - 2000 pg/ml |
| Sensitivity | 18.8 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Serum, plasma and other biological fluids. |
| Availability | Shipped within 5-12 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | Neuronal apoptosis inhibitory protein,Baculoviral IAP repeat-containing protein 1 |
| Background | CLIA Kits NAIP |
| Status | RUO |
| Note | The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
NLR Family Apoptosis Inhibitory Protein (NAIP) is a member of the NOD-like receptor (NLR) family involved in innate immunity and apoptosis regulation It plays a key role in forming the inflammasome, a multiprotein complex that activates caspase-1 leading to the maturation of IL-1β and IL-18 during immune responses NAIP recognizes bacterial flagellin and type III secretion system components triggering the activation of NLRC4 inflammasomes particularly in macrophages NAIP’s anti-apoptotic role is mediated through inhibition of caspase activity which helps protect cells during stress or infection Dysregulation of NAIP expression has been associated with neurodegenerative diseases such as spinal muscular atrophy (SMA) where deletions or mutations in the NAIP gene contribute to motor neuron degeneration Elevated levels of NAIP have also been observed in cancer cells where it aids in apoptosis resistance and tumor progression highlighting its dual role in survival and immune defense
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