Human Neurogenic Locus Notch Homolog Protein 1 (NOTCH1) Protein
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Description
Human Neurogenic Locus Notch Homolog Protein 1 (NOTCH1) Protein is a recombinant Human protein produced in a Mammalian cell expression system.
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Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Neurogenic Locus Notch Homolog Protein 1 (NOTCH1) |
| Host | Mammalian cells |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 81.95 kDa Sequence Fragment: Ala19-Gln526 Tag: C-terminal Fc tag |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB, SDS-PAGE |
| Buffer | 0.01 M PBS, pH 7.4. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8 °C if the entire vial will be used within 1 week. Aliquot and store at -20 °C for long-term storage. Avoid repeated freeze-thaw cycles. |
| Dry Ice | No |
| UniProt ID | P46531 |
| Alias | AOS5,AOVD1,TAN1,Hn1,Translocation-associated notch protein TAN-1,notch receptor 1 |
| Background | Protein NOTCH1 |
| Note | This product is for research use only. This product is shipped with ice packs. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
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anti- Notch1 antibody
This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma.
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