Human Neural Cell Adhesion Molecule (NCAM) Protein

Este producto es parte de NCAM - neural cell adhesion molecule
Human Neural Cell Adhesion Molecule (NCAM) Protein

Pida mas información

935106861

info@markelab.com

Precio

195€ (10 µg)

Protein NCAM1

proveedor

Abbexa

reference

abx068230

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Human Neural Cell Adhesion Molecule (NCAM) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).


Background

Neural Cell Adhesion Molecule 1 (NCAM1), also known as CD56, is a member of the immunoglobulin (Ig) superfamily and plays a critical role in cell-cell adhesion, neuronal development, and synaptic plasticity. NCAM1 is a transmembrane glycoprotein with alternative splice variants and glycosylation modifications, including polysialic acid (PSA) attachment, which regulates its function. Structurally, NCAM1 consists of five extracellular Ig-like domains, two fibronectin type III domains, a transmembrane domain, and a cytoplasmic tail involved in intracellular signaling. NCAM1 is highly expressed in the nervous system, where it facilitates neuronal migration, axonal growth, and the formation of synaptic connections during development. PSA-modified NCAM1 reduces adhesion and promotes neuronal plasticity. In adults, NCAM1 continues to regulate synapse maintenance, memory formation, and neuroregeneration. It is also expressed in other cell types, including natural killer (NK) cells, where it mediates immune recognition.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Neural Cell Adhesion Molecule (NCAM)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 33.3 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Thr340-Val608 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

NCAM1


dry ice

No


availability

Shipped within 5-7 working days.


alias

CD56,NCAM,MSK39,N-CAM-1


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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