Human Muscarinic Acetylcholine Receptor M5 (CHRM5) Peptide (OVA)
442€ (100 µg)
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Name
Human Muscarinic Acetylcholine Receptor M5 (CHRM5) Peptide (OVA)
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx651261
Tested Applications
WB, SDS-PAGE
Description
Human Muscarinic Acetylcholine Receptor M5 (CHRM5) Peptide (OVA) is a Human protein conjugated to OVA.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Muscarinic Acetylcholine Receptor M5 (CHRM5) |
| Host | Synthetic |
| Assay Type | Activity: Not tested Sequence Fragment: His7-Arg24 |
| Origin | Human |
| Conjugation | OVA |
| Expression | Synthetic |
| Purity | > 90% |
| Size 1 | 100 µg |
| Size 2 | 200 µg |
| Size 3 | 500 µg |
| Size 4 | 1 mg |
| Size 5 | 5 mg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | P08912 |
| Gene ID | 1133 |
| OMIM | 118496 |
| Alias | CHRM5,M5R,cholinergic receptor, muscarinic 5,cholinergic receptor,M5 receptor,HM5 |
| Background | Protein CHRM5 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Background
CHRM5 encodes the muscarinic acetylcholine receptor M5, the least abundant subtype of the muscarinic receptor family. Unlike CHRM4, CHRM5 primarily couples to Gq/11 proteins, activating phospholipase C (PLC) and increasing the production of inositol triphosphate (IP3) and diacylglycerol (DAG). This cascade results in an elevation of intracellular calcium ion levels and downstream activation of protein kinase C (PKC). CHRM5 is expressed in limited regions of the central nervous system, including the midbrain dopamine neurons, hippocampus, and vascular endothelial cells. Its activation plays a key role in cerebral blood flow regulation, dopamine release, and synaptic plasticity, which are critical for processes such as learning, memory formation, and reward processing. CHRM5 is also implicated in addiction and substance abuse disorders, as its activation enhances dopamine release in the brain's reward centers. CHRM5-selective agonists are of therapeutic interest for improving cognitive function in diseases like Alzheimer's disease and vascular dementia, while antagonists could be useful for modulating excessive cholinergic activity. Additionally, CHRM5 is explored for its role in promoting vasodilation of cerebral arteries, which may have implications in treating stroke or ischemic conditions. Genetic variants of CHRM5 are associated with susceptibility to neurodegenerative diseases, emphasizing its role as a critical therapeutic target in neurology and psychiatry.
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