Human MMP-2(Matrix Metalloproteinase 2) ELISA Kit

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935106861

info@markelab.com

Precio

Precio a consultar

proveedor

FineTest

reference

EH0017

Tested Applications

reactivity

human

status

RUO

clonality

Background

MMPs are secreted by diverse connective tissue and pro-inflammatory cells. Typically, these enzymes exhibit minimal expression under normal physiological circumstances. MMPs assume a pivotal role in various cellular processes, including cell proliferation, migration, differentiation, angiogenesis, apoptosis, and immunity. They share a common domain structure, consisting of three key components. First is the pro-peptide, which requires removal to activate the enzyme. Next, there is the catalytic domain, featuring a cysteine switch, where a cysteine residue interacts with zinc, and the haemopexin-like C-terminal domain is linked to the catalytic domain via a flexible hinge region. Matrix metalloproteinase-2 (MMP-2), also referred to as gelatinase A, is an enzyme encoded by the MMP2 gene in humans. MMP-2 exhibits a wide range of substrates, including gelatin, collagen types I, II, III, IV, Vii, and X. It has been implicated in various aspects of cancer, including therapy, angiogenesis, and cell signaling. Among its aliases are CLG4, Gelatinase A, 72kDa Gelatinase, 72kDa Type IV Collagenase, Matrix Metalloproteinase-II, and Collagenase Type IV-A.


MMPs son secretadas por diversos tejidos conectivos y células proinflamatorias. Normalmente, estas enzimas exhiben una expresión mínima en circunstancias fisiológicas normales. Las MMP asumen un papel fundamental en diversos procesos celulares, incluida la proliferación, migración, diferenciación, angiogénesis, apoptosis e inmunidad celular. Comparten una estructura de dominio común, que consta de tres componentes clave. El primero es el propéptido, que requiere eliminación para activar la enzima. A continuación, está el dominio catalítico, que presenta un interruptor de cisteína, donde un residuo de cisteína interactúa con el zinc, y el dominio C-terminal similar a hemopexina está unido al dominio catalítico a través de una región bisagra flexible. MMP-2, también conocida como gelatinasa A, es una enzima codificada por el gen MMP2. En humanos. MMP-2 exhibe una amplia gama de sustratos, incluidos gelatina, colágeno de tipo I, II, III, IV, Vii y X. Se ha implicado en diversos aspectos del cáncer, incluida la terapia, la angiogénesis y la señalización celular. Entre sus alias se encuentran CLG4, Gelatinasa A, Gelatinasa de 72 kDa, Colagenasa Tipo IV de 72 kDa, Metaloproteinasa de Matriz-II y Colagenasa Tipo IV-A.

Características del producto

category

ELISA Kits


size 1

96T


storage

2-8 °C for 6 months


uniprot id

P08253


test range

0.5-32ng/ml


detection method

Colorimetric


assay type

Sandwich ELISA, Double Antibody


assay data

Quantitative


availability

Shipped within 10-14 working days.


alias

MMP-2|Matrix Metalloproteinase 2|Gelatinase A|72 kDa gelatinase|CLG4|collagenase type IV-A|72 kDa type IV collagenase


short name

MMP-2


status

RUO


sample type

Serum,Plasma,Tissue homogenates,Other biological fluids


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