Human Methylcytosine Dioxygenase TET3 (TET3) ELISA Kit
715€ (96 tests)
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935106861
info@markelab.com
name
Human Methylcytosine Dioxygenase TET3 (TET3) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx549341
tested applications
ELISA
Description
Human Methylcytosine dioxygenase TET3 (TET3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Methylcytosine dioxygenase TET3 (TET3) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Methylcytosine Dioxygenase TET3 (TET3) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.78 ng/ml - 50 ng/ml |
| Sensitivity | < 0.34 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | O43151 |
| Gene ID | 200424 |
| OMIM | 613555 |
| Alias | FLJ20032, KIAA1546, MDS, Methylcytosine dioxygenase TET2, Nbla00191, Probable methylcytosine dioxygenase TET2, Protein Ayu17 449, Tet 2, Tet methylcytosine dioxygenase 2, Tet oncogene 2, Tet oncogene family member 2, TET2, TET2_HUMAN |
| Background | Elisa kits for TET3 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
TET3 is a dioxygenase enzyme that converts 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), driving active DNA demethylation and playing a critical role in epigenetic reprogramming. TET3 is predominantly expressed during early embryonic development, oocyte maturation, and zygotic genome activation, where it facilitates global DNA demethylation and ensures proper gene activation for development. In somatic tissues, TET3 is involved in regulating neuronal differentiation, synaptic plasticity, and DNA repair pathways. TET3 plays a pivotal role in brain development and neurogenesis, where it ensures transcriptional flexibility required for cellular identity and maturation. Dysregulation of TET3 has been associated with neurological disorders, aging, and cancer, where altered DNA methylation patterns disrupt gene expression and cellular homeostasis. Knockout studies reveal defects in embryogenesis, impaired neurodevelopment, and increased genomic instability, underscoring TET3's essential role in DNA methylation reprogramming, neuronal function, and developmental regulation.
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