Human Methylcytosine Dioxygenase TET3 (TET3) ELISA Kit
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Pida mas información
935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for TET3
proveedor
Abbexareference
abx549341Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Methylcytosine dioxygenase TET3 (TET3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Methylcytosine dioxygenase TET3 (TET3) concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
TET3 is a dioxygenase enzyme that converts 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), driving active DNA demethylation and playing a critical role in epigenetic reprogramming. TET3 is predominantly expressed during early embryonic development, oocyte maturation, and zygotic genome activation, where it facilitates global DNA demethylation and ensures proper gene activation for development. In somatic tissues, TET3 is involved in regulating neuronal differentiation, synaptic plasticity, and DNA repair pathways. TET3 plays a pivotal role in brain development and neurogenesis, where it ensures transcriptional flexibility required for cellular identity and maturation. Dysregulation of TET3 has been associated with neurological disorders, aging, and cancer, where altered DNA methylation patterns disrupt gene expression and cellular homeostasis. Knockout studies reveal defects in embryogenesis, impaired neurodevelopment, and increased genomic instability, underscoring TET3's essential role in DNA methylation reprogramming, neuronal function, and developmental regulation.
Características del producto
category
ELISA Kits
immunogen target
Methylcytosine Dioxygenase TET3 (TET3)
reactivity
Human
test range
0.78 ng/ml - 50 ng/ml
sensitivity
< 0.34 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
FLJ20032, KIAA1546, MDS, Methylcytosine dioxygenase TET2, Nbla00191, Probable methylcytosine dioxygenase TET2, Protein Ayu17 449, Tet 2, Tet methylcytosine dioxygenase 2, Tet oncogene 2, Tet oncogene family member 2, TET2, TET2_HUMAN
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
TET3
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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