Human Methylcytosine Dioxygenase TET2 (TET2) ELISA Kit

Human Methylcytosine Dioxygenase TET2 (TET2) ELISA Kit
715€ (96 tests)

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Name
Human Methylcytosine Dioxygenase TET2 (TET2) ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx383703
Tested Applications
ELISA

Description

Human Methylcytosine Dioxygenase TET2 (TET2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human TET2 concentrations in serum, plasma and other biological fluids.

Documentos del producto

Instrucciones
Descargar
Data sheet
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Especificaciones del producto

Category
ELISA Kits
Immunogen Target
Methylcytosine Dioxygenase TET2 (TET2)
Reactivity
Human
Detection Method
Colorimetric
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
15.6 pg/ml - 1000 pg/ml
Sensitivity
< 9.38 pg/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Form
Standard Form: Lyophilized
Tested Applications
ELISA
Sample Type
Serum, plasma and other biological fluids.
Availability
Shipped within 5-12 working days.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
Q6N021
Gene ID
54790
OMIM
263300
Alias
IMD75,KIAA1546,MDS
Background
Elisa Kits for: TET2
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.

Background

TET2 is a member of the TET family of dioxygenases that catalyzes the conversion of 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) in DNA, promoting active DNA demethylation and epigenetic regulation. TET2 is widely expressed in hematopoietic cells and plays a critical role in stem cell self-renewal, differentiation, and lineage commitment. It acts as a tumor suppressor by maintaining genomic stability and ensuring proper gene expression patterns, particularly in hematopoiesis. Loss-of-function mutations in TET2 are frequently observed in myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), and other hematological malignancies, where they disrupt DNA methylation balance, alter gene regulation, and promote uncontrolled proliferation. TET2 also regulates immune responses by modulating T cell differentiation and inflammatory gene expression. Knockout studies in mice demonstrate enhanced hematopoietic stem cell self-renewal, impaired differentiation, and increased susceptibility to leukemogenesis, emphasizing TET2's role in DNA methylation dynamics, tumor suppression, and immune regulation.

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