Human Methylcytosine Dioxygenase TET2 (TET2) ELISA Kit
715€ (96 tests)
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name
Human Methylcytosine Dioxygenase TET2 (TET2) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx383703
tested applications
ELISA
Description
Human Methylcytosine Dioxygenase TET2 (TET2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human TET2 concentrations in serum, plasma and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Methylcytosine Dioxygenase TET2 (TET2) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 15.6 pg/ml - 1000 pg/ml |
| Sensitivity | < 9.38 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Serum, plasma and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q6N021 |
| Gene ID | 54790 |
| OMIM | 263300 |
| Alias | IMD75,KIAA1546,MDS |
| Background | Elisa kits for TET2 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
TET2 is a member of the TET family of dioxygenases that catalyzes the conversion of 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) in DNA, promoting active DNA demethylation and epigenetic regulation. TET2 is widely expressed in hematopoietic cells and plays a critical role in stem cell self-renewal, differentiation, and lineage commitment. It acts as a tumor suppressor by maintaining genomic stability and ensuring proper gene expression patterns, particularly in hematopoiesis. Loss-of-function mutations in TET2 are frequently observed in myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), and other hematological malignancies, where they disrupt DNA methylation balance, alter gene regulation, and promote uncontrolled proliferation. TET2 also regulates immune responses by modulating T cell differentiation and inflammatory gene expression. Knockout studies in mice demonstrate enhanced hematopoietic stem cell self-renewal, impaired differentiation, and increased susceptibility to leukemogenesis, emphasizing TET2's role in DNA methylation dynamics, tumor suppression, and immune regulation.
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The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The encoded protein is involved in myelopoiesis, and defects in this gene have been associated with several myeloproliferative disorders. Two variants encoding different isoforms have been found for this gene.
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