Human Metabotropic glutamate receptor 7 (GRM7) ELISA Kit
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Description
Human Metabotropic glutamate receptor 7 (GRM7) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Metabotropic glutamate receptor 7 (GRM7) concentrations in tissue homogenates, cell lysates and other biological fluids.
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Product specifications
| Category | ELISA Kits |
| Immunogen Target | Metabotropic glutamate receptor 7 (GRM7) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q14831 |
| Gene ID | 2917 |
| OMIM | 604101 |
| Alias | GRM7,GLUR7,GPRC1G,MGLU7,MGLUR7,NEDSHBA,PPP1R87, mGluR7,mGlu7a receptor |
| Background | Elisa kits for GRM7 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
GRM7, or mGluR7, is a Group III metabotropic glutamate receptor widely expressed in the central nervous system, including the hippocampus, amygdala, and cerebellum. It functions as a presynaptic autoreceptor, coupling to Gi/o proteins to inhibit adenylate cyclase, decrease cAMP production, and suppress glutamate release. GRM7 plays a key role in synaptic plasticity, neuroprotection, and neuronal excitability, contributing to learning, memory, and emotional regulation. Dysregulation of GRM7 signaling is linked to psychiatric and neurological disorders, including anxiety, depression, schizophrenia, and epilepsy, where imbalanced glutamatergic transmission disrupts synaptic function. GRM7 activation has neuroprotective effects, reducing excitotoxicity and oxidative stress in neurodegenerative conditions. Positive allosteric modulators (PAMs) and selective agonists of GRM7 are being explored as therapeutic agents for anxiety, mood disorders, and epilepsy, highlighting its potential in restoring synaptic balance and neuroprotection.
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