Human Metabotropic Glutamate Receptor 2 (GRM2) ELISA Kit
715€ (96 tests)
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name
Human Metabotropic Glutamate Receptor 2 (GRM2) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx259694
tested applications
ELISA
Description
Human Metabotropic Glutamate Receptor 2 (GRM2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human mGluR2 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Metabotropic Glutamate Receptor 2 (GRM2) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.312 ng/ml - 20 ng/ml |
| Sensitivity | < 0.14 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q14416 |
| Gene ID | 2912 |
| OMIM | 604099 |
| Alias | GRM2,GLUR2,GPRC1B,MGLUR2,mGlu2,metabotropic glutamate receptor 2 |
| Background | Elisa kits for GRM2 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
GRM2, or mGluR2, is a Group II metabotropic glutamate receptor primarily expressed in the central nervous system, including the hippocampus, prefrontal cortex, and thalamus. GRM2 couples to Gi/o proteins, inhibiting adenylate cyclase activity and reducing cyclic AMP (cAMP) levels, leading to decreased glutamate release and dampened excitatory signaling. GRM2 functions as an autoreceptor or heteroreceptor, modulating synaptic plasticity and neuronal excitability. It plays a significant role in cognitive function, emotional regulation, and stress responses. Dysregulation of GRM2 has been associated with psychiatric disorders such as anxiety, schizophrenia, and depression, where altered glutamate signaling disrupts synaptic balance. GRM2 agonists have shown promise as therapeutic agents for mood and anxiety disorders, as they reduce excessive glutamate release and normalize neuronal signaling. GRM2 is also being investigated for its role in addiction and neurodegeneration, making it a key target for psychiatric and neurological therapies.
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