Human Membrane Cofactor Protein (CD46) Protein
234€ (2 µg)
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Name
Human Membrane Cofactor Protein (CD46) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx680005
Tested Applications
SDS-PAGE
Description
Human Membrane Cofactor Protein (CD46) Protein is a recombinant protein produced in Sf9, Baculovirus cells.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Membrane Cofactor Protein (CD46) |
| Host | Insect |
| Origin | Human |
| Conjugation | Unconjugated |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 2 µg |
| Size 2 | 10 µg |
| Size 3 | 1 mg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Availability | Shipped within 5-10 working days. |
| Dry Ice | No |
| Alias | MCP,TLX,AHUS2,MIC10,TRA2.10,Membrane cofactor protein,Trophoblast leukocyte common antigen |
| Background | Protein CD46 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
CD46, also known as membrane cofactor protein (MCP), is a transmembrane glycoprotein that serves primarily as a regulatory component of the complement system, protecting host cells from complement-mediated damage. CD46 is widely expressed on almost all nucleated cells and plays a key role in immune regulation, ensuring that the complement system, which is responsible for clearing pathogens, does not attack the body’s own cells. CD46 does this by serving as a cofactor for the proteolytic cleavage of C3b and C4b, two crucial components of the complement pathway, which are inactivated by factor I. In addition to its role in the complement system, CD46 is involved in various immune functions, including modulation of T-cell responses, immune tolerance, and viral entry. Several viruses, such as the measles virus and human herpesvirus 6 (HHV-6), use CD46 as a receptor to gain entry into host cells, highlighting its involvement in viral pathogenesis.
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