Human Melatonin Receptor 1B (MTNR1B) Protein
234€ (10 µg)
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935106861
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name
Human Melatonin Receptor 1B (MTNR1B) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx654339
tested applications
WB, SDS-PAGE
Description
Human Melatonin Receptor 1B (MTNR1B) Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Melatonin Receptor 1B (MTNR1B) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Gly309-Leu362 Tag: N-terminal His and GST tags |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 36.0 kDa Observed MW: 40 kDa |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| Alias | MTNR1B,mel1b receptor |
| Background | Protein MTNR1B |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Descripción
MTNR1B, also known as MT2, is a G protein-coupled receptor for melatonin, expressed in the retina, pancreas, and central nervous system. Like MTNR1A, MTNR1B inhibits adenylate cyclase activity through Gi proteins, reducing cAMP levels and modulating circadian rhythms, sleep regulation, and metabolic processes. MTNR1B plays a critical role in glucose metabolism by regulating insulin secretion in pancreatic β-cells, where melatonin signaling affects insulin release and glucose homeostasis. Genetic variants in MTNR1B have been strongly associated with an increased risk of type 2 diabetes, highlighting its role in impaired glucose tolerance and β-cell dysfunction. In the retina, MTNR1B helps regulate photoreceptor sensitivity and circadian rhythms, contributing to visual function. Dysregulation of MTNR1B signaling has been linked to sleep disturbances, metabolic disorders, and impaired glucose regulation. MTNR1B is being explored as a therapeutic target for managing type 2 diabetes, circadian rhythm disorders, and sleep-related conditions, emphasizing its dual role in metabolic and circadian regulation.
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